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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۰، شماره ۱، صفحات ۱۳-۲۰
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عنوان انگلیسی 'T-cell/Natural killer-cell neoplasms presenting as leukemia- Case series from single tertiary care center'
چکیده انگلیسی مقاله Background: Mature T/ NK-cell neoplasms are a rare group of disorders and their presentation as leukemia is even rarer. Most of the previous studies have focused on mature B-cell lineage leukemias and there is a paucity of data on mature T/NK-cell lineage leukemias. We, therefore, planned this study to analyze their spectrum, frequency, morphology and immunophenotypic features. Methods: All cases of lymphomas presenting as leukemia over a period of two and a half years were evaluated. Detailed analysis of cases with T/NK-cell lineage was done for their clinical, hematological and immunophenotypic features. Results: A total of 262 cases of mature lymphoid neoplasms presented as leukemia during the study period. Of whom, only 8 (3.1%) cases were of T /NK-cell lineage and the remaining (96.9%) were of B-cell lineage. Of 8 cases, 4 (50%) had T-prolymphocytic leukemia, 2 (25%) had chronic lymphoproliferative disorder- natural killer cell and 1 (12.5%) case of each T-large granular lymphocytic leukemia and hepatosplenic γ/δ T-NHL. Conclusion: T/NK-cell leukemias are rare. Along with clinical and morphological features, pattern of immunophenotypic markers is vital for their diagnosis and subcategorization.
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نویسندگان مقاله shano naseem | shano naseem
assistant professor, department of hematology, postgraduate institute of medical education and research, chandigarh


maninderbir kaur | maninderbir kaur
senior resident, department of hematology, postgraduate institute of medical education and research, chandigarh


ایمان updesh سینگ sachdeva | man updesh singh sachdeva
assistant professor, department of hematology, postgraduate institute of medical education and research, chandigarh


jasmina ahluwalia | jasmina ahluwalia
associate professor, department of hematology, postgraduate institute of medical education and research, chandigarh


reena داس | reena das
professor, department of hematology, postgraduate institute of medical education and research, chandigarh


neelam ورما | neelam varma
professor and head, department of hematology, postgraduate institute of medical education and research, chandigarh


subhash ورما | subhash varma
professor and head, department of internal medicine, postgraduate institute of medical education and research, chandigarh
نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/470
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