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Iranian Journal of Pharmaceutical Sciences، جلد ۱۲، شماره ۴، صفحات ۴۳-۵۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The modulating effect of glucocorticoids and opioid system on anxiety related behavior in young and adult rats |
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| چکیده انگلیسی مقاله |
One of the main components of the stress system is hypothalamus- pituitary-adrenal (HPA) axis. Acute activation of µ-opioid receptors increases the activity of the HPA axis, leading to release of ACTH and corticosterone. Glucocorticoids can change behaviors, depend on age but there were no evidences about the interaction between age, opioid system and glucocorticoids. In this experiment, effects of dexamethasone (1mg/kg) and RU486 (20mg/kg) as an agonist and antagonist of glucocorticoid receptors, morphine (5mg/kg) and naloxone (20mg/kg) as an agonist and antagonist of the opioid system on anxiety in young and adult male Wistar rats were examined. The percentage of time in the open arms of plus maze was evaluated for anxiety behavior also percentage of the number of entries in closed arms was evaluated for locomotor activity. The results showed that morphine (5mg/kg) and dexamethasone (1mg/kg) had an anxiolytic effect on both young and adult rats while just in young rats reduced locomotor activity. RU486 could prevent the anxiolytic effect of morphine, and the anxiolytic effect of dexamethasone had been inhibited by naloxone in young but it wasn't seen in adult rats. These results show an interactive effect between glucocorticoids and the opioid system on mediating anxiety that can be influenced by age. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
مهناز کسمتی |
department of biology, faculty of sciences, shahid chamran university, ahvaz, iran
سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)
مریم رضایی |
department of biology, faculty of sciences, shahid chamran university, ahvaz, iran
سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)
مژگان ترابی |
department of biology, faculty of sciences, shahid chamran university, ahvaz, iran
سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)
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| نشانی اینترنتی |
http://www.ijps.ir/article_25446_5ae25ffeccd8b41688a34456cd232f89.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/200/article-200-399103.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
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