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Journal of Arthropod-Borne Diseases، جلد ۶، شماره ۲، صفحات ۱۳۶-۱۴۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of Iranian Honey bee (Apis mellifera) Venom on Blood Glucose and In- sulin in Diabetic Rats
چکیده انگلیسی مقاله B a ckground: Diabetes is an important disease. This disease is a metabolic disorder characterized by hyperglycemia resulting from perturbation in insulin secretion, insulin action or both. Honey bee venom contains a wide range of polypeptide agents. The principle components of bee venom are mellitin and phospholipase A2. These components increase insulin secretion from the β-cells of pancreas. This study was conducted to show the hypoglycemic effect of honey bee venom on alloxan induced diabetic male rats. M e t hods: Eighteen adult male rats weighting 200±20 g were placed into 3 randomly groups: control, alloxan mono- hydrate-induced diabetic rat and treated group that received honey bee venom daily before their nutrition for four months. Forty eight hours after the last injection, blood was collected from their heart, serum was dissented and blood glucose, insulin, triglyceride and total cholesterol were determined. Results: Glucose serum, triglyceride and total cholesterol level in treated group in comparison with diabetic group was significantly decreased (P< 0.01). On the other hand, using bee venom causes increase in insulin serum in com- parison with diabetic group (P< 0.05). Conclusion: Honeybee venom (apitoxin) can be used as therapeutic option to lower blood glucose and lipids in dia- betic rats.
کلیدواژه‌های انگلیسی مقاله Alloxan, Glucose, Honeybee Venom, Rat
نویسندگان مقاله seyyedehmahbubeh موسوی | seyyedehmahbubeh mousavi
department of entomology, islamic azad university, tehran science and research branch, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

سهراب ایمانی | sohrab imani
department of toxicology, medical sciences university, semnan, iran


سعید حقیقی | saeid haghighi
department of pharmaceutical, microbiology, pasture institute of iran, tehran, iran


seyyedehelaheh موسوی | seyyedehelaheh mousavi
department of pharmacology, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

اکبر کریمی | akbar karimi
departments of developmental biology sciences, islamic azad university, tehran science and research branch, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://jad.tums.ac.ir/index.php/jad/article/view/168
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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