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International Journal of Fertility and Sterility، جلد ۷، شماره ۳، صفحات ۵۳-۵۳
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عنوان انگلیسی P-43: Short Term Effect of Oxytocin on Testis under Ischemia Reperfusion Injury
چکیده انگلیسی مقاله Background: The aim of this study was to investigate the short term protective effect of oxytocin on testicular ischemia reperfusion injury immediately after detorsion in a rat model. Materials and Methods: Twenty adult rats were randomly divided into four groups: Control, Ischemia- Reperfusion (IR), Oxytocin and IR+ Oxytocin. Testicular ischemia was achieved by torsion of the left testis 720° clockwise for 2 hours. Two hours after ischemia, torsion was removed and reperfusion was performed. Immediately after reperfusion 0.03 μg/kg oxytocin were administered intraperitoneally to the IR+ Oxytocin group. Three hours after surgery left testis were removed and evaluations were made by Jhonson's score and ELISA for study of maturation of seminiferous tubules and assay of serum testosterone, FSH and LH levels respectively. Results: Torsion of testis in IR group for two hours induced degeneration of germ cells, edema and blood vessels congestion in testis. A significant reduced Jhonson's score were detected in IR group in compare with controls (p< 0.05). However there was not significant statistical difference in serum levels of testosterone, FSH and LH. Administration of oxytocin in IR+ Oxytocin group immediately after reperfusion, improved testicular histology in compare with IR group without any effect on levels of abovementioned hormones. Conclusion: Exogenous oxytocin in short term after testicular reperfusion has a protective effect on testis.
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نشانی اینترنتی http://ijfs.ir/journal/article/abstract/3503
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