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Iranian Journal of Toxicology، جلد ۱۹، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی Pulmonary Toxicity Induced by Subacute Inhalation of Polyvinyl Chloride Microplastics: Oxidative Stress and NF-κB Pathway Activation in Rat Models
چکیده انگلیسی مقاله
Background: Polyvinyl chloride (PVC) microplastics are among the most hazardous types of microplastics due to their widespread use and environmental persistence. The increasing production and degradation of PVC microplastics pose significant concerns about their adverse effects on living organisms, particularly through inhalation exposure. Materials and Methods: This study investigated the pulmonary toxicity of PVC microplastics in rat models following 28 days of subacute inhalation exposure at a dose of 15 mg/m³. Pulmonary inflammation and tissue morphology were evaluated using immunofluorescence staining for p65 NF-κB and hematoxylin and eosin (H&E) staining. Oxidative stress was assessed by measuring malondialdehyde (MDA) levels as a marker. Results: The results demonstrated that subacute inhalation exposure to PVC microplastics significantly increased MDA levels (p<0.05), indicating heightened oxidative stress. Immunofluorescence analysis revealed elevated p65 NF-κB expression (p<0.05), confirming the activation of the inflammatory pathway. Histopathological evaluation showed severe pulmonary tissue damage, including widespread inflammation and structural disruption (p<0.05). Conclusion: This study highlights that subacute inhalation of PVC microplastics induces pulmonary toxicity through mechanisms involving oxidative stress and activation of the NF-κB signaling pathway.
کلیدواژه‌های انگلیسی مقاله Microplastics, polyvinyl chloride, inhalation, pulmonary, toxicity
نویسندگان مقاله | Muhammad Reva Aditya
Department of Biomedical Sciences, Faculty of Medicine, Brawijaya University, Malang, Indonesia


| Athaya Rahmanardi Muhammad
Department of Biomedical Sciences, Faculty of Medicine, Brawijaya University, Malang, Indonesia


| Triwahju Astuti


| Hikmawan Wahyu Sulistomo
Department of Pharmacology, Faculty of Medicine, Brawijaya University, Malang, Indonesia


| Dian Nugrahenny
Department of Pharmacology, Faculty of Medicine, Brawijaya University, Malang, Indonesia
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1382-1&slc_lang=en&sid=1
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