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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۹، شماره ۴، صفحات ۴۲۴-۴۲۸
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عنوان انگلیسی Report of Granular Blasts in Adult B-Cell ALL: A Rare Morphological Mimic of AML
چکیده انگلیسی مقاله Granular ALL is one of the uncommon morphological variants of acute lymphoblastic leukemia (ALL), characterized by cytoplasmic granules in lymphoid blasts. This rare morphological presentation may lead to diagnostic misinterpretation. Case reports of such presentations enhance understanding of disease biology and therapeutic considerations. Case presentation: A 22-year-old woman with Granular ALL has been discussed here. In the Peripheral blood smear (PBS) of this patient, cytoplasmic granules were identified in the cytoplasm of lymphoblasts. Further examinations were conducted on the bone marrow aspiration (BMA) sample of the patient, including karyotyping, flowcytometric and conventional molecular evaluations for ALL.  The flow cytometric results were consistent with a diagnosis of B-ALL; the karyotyping analysis showed 47, XX, +17[4], and molecular findings revealed no detectable abnormalities. Conclusion: Due to the misdiagnosis of Granular ALL as AML, the identification of distinguishing diagnostic features of Granular ALL is clinically significant. In this context, flow cytometric, cytogenetic, and molecular findings are invaluable to distinguish between these two types of acute leukemia.  
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نویسندگان مقاله | Morteza Garmei
Department of Hematology and Blood Banking, Mashhad University of Medical Sciences, Mashhad, Iran


| Arefeh Mazhari
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Hadi Sadeghian
1) Department of Hematology and Blood Banking, Mashhad University of Medical Sciences, Mashhad, Iran 2)Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Fatemeh Shams
1) Department of Hematology and Blood Banking, Mashhad University of Medical Sciences, Mashhad, Iran 2) Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Hossein Ayatollahi
1) Department of Hematology and Blood Banking, Mashhad University of Medical Sciences, Mashhad, Iran 2) Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Maryam Sheikhi
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Elham Jafaei
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Amirali Ayatollahi
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Yasamin Minaeitorshizi
Department of Hematology and Blood Banking, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/2415
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