این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Microbiology، جلد ۱۷، شماره ۵، صفحات ۷۲۵-۷۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Incidence of drug resistance and expression of blaOXA-51 and adeA genes among Acinetobacter baumannii strains isolated from hospitalized patients at a government hospital in Irbid, Jordan
چکیده انگلیسی مقاله Background and Objectives: Acinetobacter baumannii (A. baumannii) is an opportunistic bacterial pathogen principally related with hospital-acquired infections. This study aimed to isolate and identify A. baumannii strains, investigate their resistance to various antibiotics, and characterize A. baumannii at the molecular level. Materials and Methods: A total of 100 samples were obtained from various hospital departments, including the intensive care unit (ICU), emergency room, kidney dialysis and surgery units. The incidence of drug resistance was studied using the Vitek 2 Compact system and further using molecular techniques such as polymerase chain reaction to analyze the genes responsible for resistance. Results: The study exhibited a high prevalence of multidrug-resistant (MDR) A. baumannii isolates, especially in ICU patients. The males were the predominant group, accounting for 60% whereas females were 40%. The most frequent samples were from urine (43%) and skin (24%). Majority of samples were from the ICU (42%) and emergency departments (20%). The tested isolates exhibited the highest resistance (66%) to oxacillin, whereas the maximum sensitivity (52%) was recorded for Erythromycin. Molecular analysis revealed the occurrence of resistance genes blaOXA-23, blaOXA-24, blaOXA-51, and blaOXA-58, which contribute to carbapenem resistance. Conclusion: The findings emphasize that A. baumannii remains a formidable nosocomial pathogen, and there is pressing requirement for enhanced infection control procedures and antibiotic stewardship. Through improved molecular observation, judicious use of antibiotics and improved infection control practices, healthcare providers can alleviate the impact of MDR A. baumannii infections and improve the prognosis for affected patients in Jordan and beyond.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Aya Maytah
Department of Basic Sciences, Ma′an University College, Al-Balqa Applied University, Ma′an, Jordan


| Omar AlKofahi
Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Zarqa University, Zarqa, Jordan


| Rania Al-Groom
Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Zarqa University, Zarqa, Jordan; Department of Allied Medical Sciences, Zarqa University College, Al-Balqa Applied University, Zarqa, Jordan


| Mohd Sajjad Ahmad Khan
Department of Basic Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia


| Basem Fouad Dababneh
Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan


| Anas Da'meh
Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Zarqa University, Zarqa, Jordan


| Rahaf Alsarayereh
Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Zarqa University, Zarqa, Jordan


| Fuad Alhawarat
Department of Applied Medical Sciences, Al Hussein Bin Abdullah II Academy for Civil Protection, Al-Balqa Applied University, Salt, Jordan


| Ghina AlSaraireh
Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Zarqa University


| Heba Ahmad Al Shqairat
Precision Medical Lab (PMLAB), AL-Karak, Jordan
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/5606
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات