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Basic and Clinical Cancer Research، جلد ۱۶، شماره ۳، صفحات ۱۶۰-۱۷۰
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عنوان انگلیسی A review of the role of enterotoxigenic Bacteroides fragilis in the development of colorectal cancer
چکیده انگلیسی مقاله Enterotoxigenic Bacteroides fragilis (ETBF) plays a significant role in the development and progression of colorectal cancer (CRC) through the production of Bacteroides fragilis toxin (BFT). This toxin activates Wnt, NF-κB, and STAT3 signaling pathways, leading to chronic inflammation, DNA damage, and abnormal cellular proliferation. The presence of ETBF in the gut microbiota can increase the risk of CRC by enhancing immune cell infiltration, triggering inflammatory responses, and disrupting cell cycle regulation. ETBF detection is performed using molecular methods such as polymerase chain reaction (PCR) and immunomagnetic separation-PCR (IMS-PCR), which offer high accuracy in identifying this bacterium. Immunomagnetic separation enhances the sensitivity and precision of detection. In addition to precise diagnostic methods, preventive strategies play a crucial role in reducing the risk of CRC. A healthy diet, including increased fiber intake, reduced consumption of processed meats and saturated fats, along with maintaining a healthy weight and regular physical activity, are among the effective factors in preventing this disease. Furthermore, stress reduction and avoidance of alcohol and tobacco can positively impact lowering the risk of CRC. A deeper understanding of the role of ETBF in CRC and its effects on molecular pathways can contribute to the development of novel preventive approaches. Investigating the composition of the gut microbiota and implementing preventive strategies based on lifestyle modifications not only aids in identifying at-risk individuals but also plays a significant role in reducing the prevalence and progression of this disease.
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نویسندگان مقاله | Abolfazl Jafari-Sales
Department of Microbiology, Kazerun Branch, Islamic Azad University, Kazerun, Iran


| Maryam Farahnaki-Sadabadi
Department of Cellular and Molecular Biology, Tabriz Branch, Islamic Azad University, Tabriz, Iran


| Elham Nozohour-Leilabadi
Department of Microbiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran


| Negin Yagoubi Azar
Department of Microbiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran


| Maryam Safari
Department of Microbiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran


| Mehrdad Pashazadeh
1. Infectious Diseases Research Center, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran
نشانی اینترنتی https://bccr.tums.ac.ir/index.php/bccrj/article/view/568
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