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International Journal of Fertility and Sterility، جلد ۱۹، شماره ۴، صفحات ۴۱۱-۴۲۰
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عنوان انگلیسی Endometrial Steroid Receptor Dysregulation and Its Association with Vitamin D, AMH, and Inflammation in Recurrent Implantation Failure: A Case-Control Study
چکیده انگلیسی مقاله Background: Defects in endometrial receptivity are significant factors in infertility and recurrent implantation
failure (RIF) during in vitro fertilization (IVF). This study aimed to evaluate the expression levels of
steroid hormone receptors and circulating biomarkers in women with RIF compared to fertile controls.
Materials and Methods: This case-control study was conducted in Tehran from June 2021 to December 2023,
involving 50 fertile women as controls and 50 women with unexplained RIF referred to the RIF Medical Center at
Arash Hospital. Blood samples and endometrial biopsies were collected at the day of the LH surge was LH 0. The
expression levels of estrogen receptors (ESR-α and ESR-β) and progesterone receptor B (PGR-B) in endometrial
tissue were assessed using real-time polymerase chain reaction (RT-PCR). Serum levels of estrogen were measured
by enzyme-linked immunosorbent assay (ELISA).
Results: Women with RIF exhibited significantly higher ESR-α expression and lower ESR-β and PGR-B expression
compared to fertile women (P<0.001). A positive correlation was found between ESR-α gene expression and
hs-CRP levels, while ESR-β and PGR-B were associated with AMH concentrations. RIF patients showed lower
serum levels of AMH and Vit-D3, but elevated hs-CRP. Fertile women demonstrated a positive association between
PGR-B expression and Vit-D3 levels. The ROC curve analysis revealed high discrimination power for the expression
of ESR-α (AUC 1.00), ESR-β (0.988), and PGR-B (0.898).
Conclusion: The study links endometrial PGR-B expression and vitamin D3 levels to decidualization and inflammation
regulation. It suggests that infertility in women with RIF may stem from elevated ESR-α, increased inflammation,
and reduced ESR-β and PGR-B expression. Further research is needed on PGR-B, VDR gene expression,
and fertility biomarkers. ROC analysis indicates that endometrial steroid receptor expression, AMH, and vitamin
D3 levels could aid in diagnosing RIF.
کلیدواژه‌های انگلیسی مقاله Recurrent Implantation Failure (RIF),Estrogen Receptors,Progesterone Receptor-B,AMH,Inflammation
نویسندگان مقاله Rahim Rostami |
Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Jamileh Jahanbakhsh |
Infertility Ward, Arash Women&apos;s Hospital, Tehran University of Medical Sciences, Tehran, Iran

Elmira Mahdinia |
Department of Clinical Biochemistry, Faculty of Medicine, Golestan University of Medical Sciences, Tehran, Iran

Azadeh Rezaei |
Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Sahar Yarahmadi |
Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Nafiseh Omodiani |
Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Afsaneh Tehranian |
Department of Gynecology and Obstetrics, Arash Women&apos;s Hospital, Tehran University of Medical Sciences, Tehran, Iran

Soudabeh Fallah |
Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://www.ijfs.ir/article_720488_80bb0b41a079deba1a1d8949add629ce.pdf
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