| چکیده انگلیسی مقاله |
Introduction: Asthma, a chronic inflammatory disorder of the airways, is marked by symptoms, including dyspnea, persistent cough, and wheezing. The pathophysiology of asthma involves sustained airway inflammation, often characterized by a significant eosinophilic infiltrate in lung tissue. This study aimed to explore the potential applications of nanotechnology in asthma therapeutics and help to develop effective asthma treatments.
Method: In this review study, the articles from 2010 to 2025 were collected by searching the databases ISI Web of Science, Science Direct, Scopus, PubMed, and Google Scholar, and using their content. Combined keywords, such as “Asthma”, “Polymeric Nanoparticles”, “PHPMA”, “PLGA”, and “PAMAM”, were used to search these databases. The articles were screened based on the relevance of the title and abstract, and irrelevant articles were excluded.
Results: Current treatments for asthma, such as inhaled glucocorticoids, beta-agonists, and leukotriene antagonists, face challenges, such as side effects and drug resistance. In recent years, nanotechnology has become an innovative approach to asthma management. Polymeric nanoparticles, including chitosan, PLGA, PAMAM, and PHPMA, have been acknowledged as effective drug carriers due to their biocompatibility, capacity to regulate drug release, and improve bioavailability.
Conclusion: These nanoparticles have great potential for enhancing asthma treatment by facilitating targeted drug delivery, decreasing the necessary dosage, and safeguarding the drug from degradation. This review study examined the application of polymeric nanoparticles in asthma treatment, compared them with lipidic nanoparticles, and discussed the role of nanotechnology in novel therapeutic and diagnostic approaches for asthma. It emphasized the necessity of expanding this technology to improve the effectiveness of treatment.
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| نویسندگان مقاله |
علی حق بین | Ali Haghbin
Assistant Professor of Allergy and Clinical Immunology, Department of Pediatrics, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
استادیار آلرژی و ایمونولوژی بالینی، گروه اطفال، دانشکده پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران
امیراحمد علیزادهنیکنام | Amirahmad Alizadeh Niknam
School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
دانشکده پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران
مولود صفاری راد | Molood Safarirad
Assistant Professor of Pediatric Endocrinology and Metabolism, Department of Pediatrics, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
استادیار غدد درونریز و متابولیسم (کودکان)، گروه اطفال، دانشکده پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران
پیمان فیضی | Peyman Feizi
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
مرکز تحقیقات فرآوردههای طبیعی و گیاهان دارویی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران
احمد وثوقی مطلق | Ahmad Vosughimotlagh
Assistant Professor of Allergy and Clinical Immunology, Department of Pediatrics, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
استادیار آلرژی و ایمونولوژی بالینی، گروه اطفال، دانشکده پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران
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