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Journal of Medical Signals and Sensors، جلد ۱۴، شماره ۱۲، صفحات ۱۰-۴۱۰۳
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عنوان انگلیسی Computed Tomography Scan and Clinical-based Complete Response Prediction in Locally Advanced Rectal Cancer after Neoadjuvant Chemoradiotherapy: A Machine Learning Approach
چکیده انگلیسی مقاله Abstract Background: Treatment of locally advanced rectal cancer (LARC) involves neoadjuvant chemoradiotherapy (nCRT), followed by total mesorectal excision. Examining the response to treatment is one of the most important factors in the follow-up of patients; therefore, in this study, radiomics patterns derived from pretreatment computed tomography images in rectal cancer and its relationship with treatment response measurement criteria have been investigated. Methods: Fifty patients with rectal adenocarcinoma who were candidates for nCRT and surgery were included. The information obtained from the tumor surgical pathology report, including pathological T and N, the degree of tumor differentiation, lymphovascular invasion, and perineural invasion along with radiomics characteristics to each patient, was assessed. Modeling with disturbed forest model was used for radiomics data. For other variables, Shapiro–Wilk, Chi-Square, and Pearson Chi-square tests were used. Results: The participants of this study were 50 patients (23 males [46%] and 27 females [54%]). There was no significant difference in the rate of response to neoadjuvant treatment in between age and gender groups. According to the modeling based on combined clinical and radiomics data together, area under the curves for the nonresponders and complete respond group (responder group) was 0.97 and 0.99, respectively. Conclusion: Random forests modeling based on combined radiomics and clinical characteristics of the pretreatment tumor images has the ability to predict the response or non-response to neoadjuvant treatment in LARC to an acceptable extent.
کلیدواژه‌های انگلیسی مقاله Computed tomography, neoadjuvant chemoradiation, radiomics feature, rectal cancer
نویسندگان مقاله | Seyyed Hossein Mousavie Anijdan
Department of Radiation Oncology, School of Medicine, Babol University of Medical Sciences, Babol, Iran


| Daryush Moslemi
Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Reza Reiazi
Cancer Research Center, Babol University of Medical Sciences, Babol, Iran


| Hamid Fallah Tafti
Department of Pharmacology and Toxicology, Babol University of Medical Sciences, Babol, Iran


| Ali Akbar Moghadamnia
Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran


| Reza Paydar


نشانی اینترنتی http://jmss.mui.ac.ir/index.php/jmss/article/view/734
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نوع مقاله منتشر شده Original Articles
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