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پژوهش‌های آسیب‌ شناسی زیستی، جلد ۲۲، شماره ۴، صفحات ۱۸۱-۱۸۷
عنوان فارسی ارزیابی مقایسه‌ای اثربخشی شیر و شیر حاوی نانوکورکومین بر سمیت سرب در رده سلولی Huh۷-۱x-ARE-luc
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عنوان انگلیسی Comparative Evaluation of the Efficacy of Milk and Milk Containing Nano-Curcumin on Lead Toxicity in Huh7-1x-ARE-luc cell-line
چکیده انگلیسی مقاله Aims: Oxidative substances are chemically reactive molecules and a byproduct of oxidative metabolism. Oxidative stress is one of the most lethal mechanisms in the toxicity of heavy metals such as lead. Since curcumin is an active ingredient in turmeric and has many properties, including antioxidant properties, the present study was conducted to evaluate the effect of milk and milk containing nano-curcumin on lead toxicity and to determine the effective concentration of nano-curcumin in controlling lead toxicity.
Materials & Methods: In the present study, the Huh7-1x-ARE-luc cell line, a biosensor of oxidative stress, was treated with 30μM of lead as a strong oxidant. Then the antioxidant effect of low-fat and high-fat milk (20, 40, and 80μL), nano-curcumin in antioxidant concentrations (4 and 8μM) and simultaneous treatment with the combination of these two antioxidants was tested using Luciferase assay.
Results: Based on statistical analyses, the combination of milk and nano-curcumin (combination of 30μM lead, 20μL milk and 4μM nano-curcumin) was able to significantly reduce lead toxicity at low concentrations of milk compared to the milk without nano-curcumin (combination of 30μM lead and 80μL milk), with RLU of 1266 and 34000, respectively.
Discussion & Conclusion: Nano-curcumin reveals a stronger antioxidant effect compared to milk, and ultimately, the combination of nano-curcumin and milk greatly neutralizes lead toxicity.
کلیدواژه‌های انگلیسی مقاله Huh7-1x-ARE-luc Biosensor,lead,Nano-Curcumin,Milk,Luciferase Assay
نویسندگان مقاله S.M. Seyed Ahmadian |
Nutrition Sciences & Food Technology Research Center, Medical Sciences Branch, Islamic Azad University, Tehran, Iran

Sh. Jalili Sh. |
Research Institute of Police Science & Social Studies, Tehran, Iran

Hadi Shirzad |
Research Institute of Police Science & Social Studies, Tehran, Iran

M. Sadeghizadeh |
Genetics Department, Biological Sciences Faculty, Tarbiat Modares University, Tehran, Iran

نشانی اینترنتی https://mjms.modares.ac.ir/article_19358_a96ec41f12193dbb46800c11d419cf0a.pdf
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