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عنوان انگلیسی Investigating the Potential of Curcumin in Reducing Liver Fibrosis via Inhibition of TGF-β1 Gene Expression
چکیده انگلیسی مقاله Abstract: Introduction: Transforming growth factor (TGF)-β1 is crucial in developing liver fibrosis. Curcumin has been shown to effectively halt the advancement of liver fibrosis by inhibiting the TGF-β1/Smad signaling pathway. Nevertheless, curcumin's impact on liver fibrosis regression remains unclear. This study explored the involvement of curcumin and TGF-β1 in the regression of liver fibrosis.
Methods: An experimental male C57BL/6 mice model included 6 treatment groups. The treatment groups were injected with carbon tetrachloride (CCl4) for 4 and 6 weeks to induce liver fibrosis, negative controls were injected with olive oil. After cessation of injection, 2 of the treatment groups were given curcumin for 2 weeks. TGF-β1 expression in liver cells was analyzed by real-time PCR assay. ELISA analyzed hydroxyproline liver tissue levels. Values of p<0.05 were regarded as statistically significant.
Results: CCl4 injection induced liver fibrosis and significantly increased TGF-β1 expression and hydroxyproline levels in tissues. Curcumin administration decreased the expression of TGF-β1 and hydroxyproline levels in the liver and accelerated the regression of liver fibrosis.
Conclusion: Curcumin accelerates regression of liver fibrosis, likely through decreasing TGF-β1 expression in the liver.
Keywords: Liver fibrosis, Carbon tetrachloride, Curcumin, TGF-β1, Hydroxyproline.
کلیدواژه‌های انگلیسی مقاله Liver Fibrosis,Carbon tetrachloride,Curcumin,TGF-β1,Hydroxyproline
نویسندگان مقاله Reyhane Ebrahimi |
Department of Clinical Biochemistry, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran

Abbas Sahebghadam Lotfi |
Department of Clinical Biochemistry, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran

نشانی اینترنتی https://mjms.modares.ac.ir/article_19505_8df33dae051f7e8a2ef4fe1576021e1c.pdf
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