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عنوان انگلیسی Anxiety-like States Enhance Beta-Band Functional Connectivity Between the Olfactory Bulb and Prefrontal Cortex
چکیده انگلیسی مقاله Introduction: Anxiety disorders involve altered brain circuit dynamics, but the neural mechanisms underlying olfactory-prefrontal interactions during anxiety remain unclear. Beta oscillations are implicated in long-range neural communication and emotional processing, but their specific role in anxiety remains underexplored.
Methods: I recorded simultaneous local field potentials (LFPs) from the olfactory bulb (OB) and prefrontal cortex (PFC) in male Wistar rats during anxiety-provoking behavioral tests, including the Elevated Plus Maze (EPM) and Open Field (OF). Functional connectivity was assessed through beta-band (13–30 Hz) synchronization using cross-correlation and power correlation analyses.
Results: Behavioral tests revealed a significant increase in beta-frequency synchronization between OB and PFC during anxiogenic conditions compared to resting states. Notably, enhanced functional coupling was observed specifically in anxiogenic zones—the open arms of the EPM and the center area of the OF. These effects suggest an intensity-dependent increase in OB-PFC interaction associated with anxiety states.
Conclusion: My findings identify beta-band OB-PFC synchronization as a novel electrophysiological marker of anxiety, providing insight into sensory-executive integration during threat processing. This enhanced connectivity may contribute to the neural circuitry underlying anxiety and represents a potential target for therapeutic intervention.
کلیدواژه‌های انگلیسی مقاله Correlation,Beta oscillations,LFP
نویسندگان مقاله Ali Samii Moghaddam |
School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

نشانی اینترنتی https://mjms.modares.ac.ir/article_19543_2d0b1becebedb2f7b9e04fa0cd3a9f41.pdf
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