این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Otorhinolaryngology، جلد ۳۷، شماره ۵، صفحات ۲۳۳-۲۴۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Short-term Effects of Nortriptyline on Sleep Parameters for Residual OSA after UPPP
چکیده انگلیسی مقاله Introduction: Uvulopalatopharyngoplasty (UPPP) surgery, though helpful, may not always achieve optimal results for obstructive sleep apnea (OSA). This prospective, uncontrolled trial investigates the potential of nortriptyline in improving symptoms and sleep parameters in OSA patients who have previously undergone UPPP.Materials and Methods: This single-center study evaluated the effects of nortriptyline in 24 OSA patients who had undergone UPPP surgery one year prior. Participants underwent a type IV sleep study one night before starting nortriptyline, and one month after treatment. The study employed the Stanford Subjective Snoring Scale (SSSS) and the Epworth Sleepiness Scale (ESS) to evaluate subjective reports of snoring and daytime sleepiness.Results: The Apnea-Hypopnea Index (AHI) significantly decreased from 16.8 to 11.4 events/hour (p-value = 0.02, effect size = 0.5). Mean oxygen saturation significantly increased from 94.1% to 95.4% (p-value = 0.016, effect size = 0.6). Time spent below 90% oxygen saturation significantly decreased from 7.2% to 4.8% (p-value = 0.007, effect size = 0.73). ESS significantly decreased from 9.6 to 7.2 (p-value < 0.001, effect size = 0.89). SSSS significantly decreased from 7.1 to 3.1 (p-value = 0.002, effect size = 0.90).  Minor side effects were monitored; one participant developed excessive sleepiness, and another participant reported heart palpitations.Conclusion: This trial suggests that nortriptyline may be a promising treatment option for improving residual sleep apnea in patients who have already undergone UPPP but still experience symptoms. Further research is needed to confirm these initial results. Trial registration number: IRCT20230614058482N1 
کلیدواژه‌های انگلیسی مقاله Obstructive Sleep Apnea, Nortriptyline, Uvulopalatopharyngoplasty, Sleep surgery, Residual OSA, Sleep pharmacotherapy, Daytime sleepiness
نویسندگان مقاله | Reza Hosseini
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Pedram Borghei
‏Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Amir Alam Hospital, Tehran, Iran,


| Amin Amali
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Imam Khomeini Hospital, Tehran, Iran.


| Reihaneh Heidari
‏Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Imam Khomeini Hospital, Tehran, Iran.


| Reza Erfanian
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Amir Alam Hospital, Tehran, Iran,
نشانی اینترنتی https://ijorl.mums.ac.ir/article_26584.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات