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Iranian Journal of Medical Sciences، جلد ۵۰، شماره ۹، صفحات ۵۸۸-۵۹۶
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عنوان انگلیسی Regulatory Roles of MicroRNAs in Female and Male Human Reproduction: A Narrative Review
چکیده انگلیسی مقاله The role of microRNAs (miRNAs) in human reproduction represents an area of research, as these regulatory molecules appear to play essential roles in reproductive function. However, the current understanding of miRNAs’ regulatory mechanisms in male and female reproduction remains incomplete, with considerable contradictory evidence in the literature. This targeted review aimed to analyze high-quality studies published to date on miRNA expression patterns in female and male reproduction to elucidate their biological roles and associations with infertility, thereby updating knowledge in this field. A comprehensive review of the literature was conducted using different electronic databases and search engines, including PubMed Central, MEDLINE, and Google Scholar from the earliest available records up to 2023. This search identified 18,100 articles related to miRNA expression in infertility, polycystic ovary syndrome (PCOS), endometriosis, and biomarkers, of which 72 met our criteria for further analysis. The findings of the present study revealed that specific, stable miRNA populations exist in different tissues and cells, potentially influencing spermatogenesis and oogenesis. The extensive review of studies suggested a consistent relationship between aberrant miRNA expression patterns and infertility. Consequently, the miRNAs identified in this review might serve as valuable biomarkers for both male and female infertility and could lead to the development of novel and specialized treatments.
کلیدواژه‌های انگلیسی مقاله infertility,MicroRNAs,Spermatogenesis,Polycystic ovary syndrome,Endometriosis,Biomarkers
نویسندگان مقاله Mohadeseh Khoshandam |
Department of Reproductive Biology, Academic Center for Education, Culture, and Research (ACECR), Qom, Iran

Leila Naserpour |
Department of Reproductive Biology, Academic Center for Education, Culture, and Research (ACECR), Qom, Iran

Mohammad Taghi Hedayati Goudarzi |
Department of Cardiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

Hossein Soltaninejad |
Department of Stem Cells Technology and Tissue Regeneration, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares University, Tehran, Iran

Hadi Zare-Zardini |
Department of Biomedical Engineering, Meybod University, Meybod, Iran

Ashraf Alsavdat Hoseiny |
Department of Reproductive Biology, Academic Center for Education, Culture, and Research (ACECR), Qom, Iran

Neda Golpar Raboki |
Department of Reproductive Biology, Academic Center for Education, Culture, and Research (ACECR), Qom, Iran

Elahe Sadat Mousavi |
Department of Reproductive Biology, Academic Center for Education, Culture, and Research (ACECR), Qom, Iran

Mohammad Ali Salami |
Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

نشانی اینترنتی https://ijms.sums.ac.ir/article_51107_f2b58aa7ff467461bdae3d4fd1fb0c07.pdf
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