| چکیده انگلیسی مقاله |
Background and Purpose: People with metabolic diseases, especially those with type 2 diabetes, are more prone to development of dyslipidemia, which increases the risk of heart disease. Given the association between obesity, unhealthy lifestyle and chronic diseases, it is obvious that lifestyle modification such as regular exercise and the use of nutritional interventions and dietary supplements can be an effective strategy for the prevention, management and treatment of obesity and its related disorders. The aim of the present study was to investigate the effects of 12 weeks of resistance training and curcumin supplementation on lipid profile levels, physiological and anthropometric indices in obese men with type 2 diabetes.
Materials and Methods: This study was conducted on 44 obese men (age, 36.3±7.5 years; weight, 86.42±5.28 kg; height, 1.71±0.08 m) with type 2 diabetes. Subjects were randomly assigned to four groups of eleven: 1) Training + curcumin, 2) Training + placebo, 3) curcumin, and 4) placebo. Curcumin was administered as a 500 mg capsule daily for twelve weeks and resistance training was performed three times a week at an intensity of 70-80% of one repetition maximum for twelve weeks. Placebo was administered in the form of capsules similar to curcumin containing starch flour. Prior to the interventions and 48 hours after the last exercise session, blood samples were taken and body composition, blood pressure, and resting heart rate were measured. Blood samples were used to measure lipid profiles. To determine the differences among groups, differences between pre- and post-test values were calculated and compare by using one-way ANOVA test, and Tukey's post-hoc test was used when P<0.05.
Results: The results of one-way ANOVA showed that there was a significant difference between the changes in HDL (P<0.001), LDL (P<0.001), triglycerides (P=0.005), and total cholesterol (P=0.004) levels among the groups. The results of Tukey's post-test showed that the changes in lipid profile were greater in the Training + curcumin group than the other groups (P<0.05). Regarding body composition data, the results of one-way ANOVA showed that changes in body weight (P=0.031), body mass index (P<0.001), fat percentage (P<0.001), waist-to-hip ratio (P<0.001), and systolic (P=0.002) and diastolic (P<0.001) blood pressure were significantly different between groups, and that the changes were greater in the Training + curcumin group than the other groups. However, no significant difference was observed for the resting heart rate (P=0.474).
Conclusion: In general, taking 500 mg of curcumin daily or performing resistance training for 12 weeks can improve the lipid profile, blood pressure, and body composition of obese men with type 2 diabetes. However, if curcumin is taken along with resistance training, the improvements are greater. |