|
|
Transport Phenomena in Nano and Micro Scales، جلد ۱۲، شماره ۲، صفحات ۰-۰
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Treatment of Lung Cancer Using Magnetic Nanoparticles Hyperthermia: Simulation-Based Study and Cardiac Thermal Safety |
|
| چکیده انگلیسی مقاله |
Magnetic hyperthermia is an emerging, minimally invasive modality for targeted cancer therapy, utilizing magnetic nanoparticles (MNPs) to induce localized heating within tumors. This study presents a comprehensive simulation-based analysis of magnetic hyperthermia applied to lung cancer. A two-dimensional axisymmetric finite element model was developed, incorporating key anatomical components tumor, air cavity, muscle, bone, skin to evaluate spatial thermal profiles under physiological respiratory dynamics. Magnetite (Fe₃O₄) nanoparticles (19 nm) were subjected to an alternating magnetic field (AMF) at 300 kHz and current intensity 300 A to induce localized heating through Néel and Brownian relaxation mechanisms. The model assessed thermal propagation during inhalation and exhalation, targeting tumor ablation temperatures (42–46 °C). Simulation results confirm the feasibility and thermal safety of MNP-assisted magnetic hyperthermia for lung cancer. These findings offer a clinically relevant framework for optimizing treatment planning and nanoparticle design. The novelty of this study lies in the development of a physiologically accurate finite element simulation that incorporates respiratory dynamics. This integrated approach, combining porous media modeling with thermal distribution analysis under dynamic breathing phases, offers new insights into optimizing safe and effective hyperthermia treatments for thoracic malignancies. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
Kazhal Moetamedi |
Department of Physics, Faculty of Sciences, Bu-Ali Sina University, Hamedan
M.H. Tavakoli |
Physics Department, Bu-Ali Sina University, Hamedan 65174, I.R. Iran
Zahra Keshtpour Amlashi |
Cancer Research Center, Institute of Cancer, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan
Safoora Nikzad |
Department of Medical Physics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan
|
|
| نشانی اینترنتی |
https://chal.usb.ac.ir/article_9307_35ae139190e28f7429490a70ac50f8c2.pdf |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|