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Nanomedicine Journal، جلد ۱۲، شماره ۳، صفحات ۴۰۴-۴۲۰
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عنوان انگلیسی Lavender essential oil nanoemulsion gel as skin lightener: green formulation, full characterization, anti-melanogenesis effect, and in-vitro/in-vivo safety profile assessment
چکیده انگلیسی مقاله Objective(s): In this study, to improve anti-melanogenesis properties, the green method based on an ultrasonic approach was utilized to prepare lavender essential oil (LEO) nanoemulgel.Material and Methods: Nano-emulsion green preparation, physico-chemical characterization, inspection morphology, animal safety study, cellar toxicity and anti-pigmentation test were performed.Results: The obtained results showed that with a decline in HLB value (Hydrophilic–lipophilic balance), the mean particle size declined from 157.600±3.798 to 85.566± 2.227 nm (P< 0.05). The evaluations performed with the accelerated stability test (freeze-thaw cycle) showed stability for nanoemulgel. Other factors, such as pH, spreadability, and, viscosity were also measured. In vitro cytotoxicity studies for the revealed LEO-nanoemulsion, on the HFF normal cell line showed less toxicity (73%) than pure LEO. Moreover, LEO-nanoemulsion had a higher cytotoxic impact on B16F10 melanoma cancer cells than pure LEO. The inhibitory activity of this LEO-nanoemulsion was evaluated in melanin content, which indicated that melanin synthesis is more inhibited than LEO. Furthermore, the evaluation of the inhibitory activity presented that the inhibition of L-dopa auto oxidation (87.33± 2.45%) is better than that of LEO (74.22± 3.26%) at a concentration of 5000 µg/ml. It should be noted that no skin irritation was observed with the histo-pathological examination on Wistar rat and the dermal irritation study for the LEO-nanoemulgel.Conclusion: The results of the present study can be very useful for the introduction and local administration of LEO nanoemulgel for the management of hyperpigmentation conditions.
کلیدواژه‌های انگلیسی مقاله Lavender, Essential oil, Nanotechnology, Green method, anti-melanogenesis
نویسندگان مقاله | Mahmoud Omidi
Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran|Department of Pharmacology and Toxicology, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Katayoun Morteza-Semnani
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran


| Majid Saeedi
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran


| Mina Frahmand
Student Research Committee, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Marzie Kamali
Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Esmaeil Mohammadian
Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran|Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Seyyed Mohammad Hassan Hashemi
Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran|Department of Pharmaceutics, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
نشانی اینترنتی https://nmj.mums.ac.ir/article_25574.html
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