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Iranian Journal of Microbiology، جلد ۱۷، شماره ۳، صفحات ۴۴۱-۴۵۰
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عنوان انگلیسی Anti-candida activity of Lacticaseibacillus rhamnosus R-2002 and its possible application in candidiasis prevention
چکیده انگلیسی مقاله Background and Objectives: Probiotics are used for the treatment of yeast infections, they restore the balance in vaginal microbiome, adhere to epithelial cells, compete against pathogenic bacteria, acidify the environment, produce bacteriocins and modulate the immunity. The aim of the study was to investigate the anti-yeast activity (AYA) of the strain Lacticaseibacillus rhamnosus R-2002 against different Candida species. Materials and Methods: From 20 strains of lactic acid bacteria examined, only L. rhamnosus R-2002 strain demonstrated beneficial properties against yeast. The effects of temperature and pH on AYA and its relation to cell wall were revealed by bi-layer agar assay. The connection of AYA to the cell wall was determined with the sonicated cells. Results: R-2002 inhibited the growth of C. albicans ATCC 10291, C. tropicalis G 31 and C. albicans G4 (both isolated from vaginal samples). R-2002 maintained its AYA between a wide range of pH and its anti-yeast component/s are extracellular. The tested strain demonstrated stability against the high concentrations of progesterone and metronidazole, making it a suitable candidate for the mitigation of vaginitis. Conclusion: The present study summarizes all the positive features of the strain R-2002 and its potential as a therapeutic agent in the treatment of candidiasis.
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نویسندگان مقاله | Aleksanyan Tigran
Department of Biochemistry, Microbiology and Biotechnology, Faculty of Biology, Institute of Biology, Yerevan State University, Yerevan, Armenia


| Hakobyan Lusine
Department of Biochemistry, Microbiology and Biotechnology, Faculty of Biology, Institute of Biology, Yerevan State University, Yerevan, Armenia


| Harutyunyan Ruzanna
Department of Biochemistry, Microbiology and Biotechnology, Faculty of Biology, Institute of Biology, Yerevan State University, Yerevan, Armenia


| Semerjyan Inesa
Department of Biochemistry, Microbiology and Biotechnology, Faculty of Biology, Institute of Biology, Yerevan State University, Yerevan, Armenia


| Nahapetyan Nelli
Department of Obstetrics and Gynecology, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia


| Gharibyan Edita
Department of Pregnancy Pathology, Erebuni Medical Center, Yerevan, Armenia


| Haertlé Thomas
Laboratory of Biopolymères, Interactions, Assemblages (BIA), Institut National de la Recherche Agronomique, Imp. Yvette Cauchois, Nantes, France


| Bazukyan Inga
Department of Biochemistry, Microbiology and Biotechnology, Faculty of Biology, Institute of Biology, Yerevan State University, Yerevan, Armenia
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/5269
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