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Iranian Journal of Microbiology، جلد ۱۷، شماره ۳، صفحات ۴۰۴-۴۱۰
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عنوان انگلیسی Evaluation of the prevention, treatment and synergistic activity between Helicobacter pylori IgY antibodies and pantaprazole on AGS cell line and C57BL/6 Mice
چکیده انگلیسی مقاله Background and Objectives: The growing resistance of Helicobacter pylori to antibiotics poses significant challenges in managing gastric ulcers. The application of IgY antibodies against H. pylori is a promising strategy. The current study evaluated the preventive and synergistic effects of IgY antibodies in conjunction with pantoprazole for treating H. pylori infection. Materials and Methods: This investigation specifically focused on the inhibitory effects of IgY in the AGS cell line infected with H. pylori. In addition, the synergistic activity of IgY with pantoprazole and its preventive and therapeutic effects were assessed in male C57BL/6 mice. Results: The findings indicated that IgY antibodies possess a substantial inhibitory effect on the adhesion of H. pylori to the AGS cell line. Furthermore, IgY antibodies resulted in a significant reduction (P<0.05) in the population of H. pylori and the severity of gastritis in infected C57BL/6 mice in both treatment and prevention groups. Notably, the optimal outcome was observed when IgY was administered alongside pantoprazole. Conclusion: The use of IgY has the potential to repair damaged cells and prevent infection by decreasing bacterial adherence to gastric epithelial cells. Given its synergistic effect with pantoprazole, IgY can be recommended as a suitable complementary treatment in conjunction with pantoprazole.
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نویسندگان مقاله | Sara Kamal Shahsavar
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Zahra Esmaeili
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Hamid Ariannejad
Department of Animal Sciences, School of Agriculture, Ferdowsi University, Mashhad, Iran


| Mohammadreza Nassiri
Department of Animal Sciences, School of Agriculture, Ferdowsi University, Mashhad, Iran


| Ali Beheshti Namdar
Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Amir Hossein Jafarian
Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Ramin Sadeghi
Department of Nuclear Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Vahid Reza Dabbagh
Department of Nuclear Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Kiarash Ghazvini
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/5036
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