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Middle East Journal of Digestive Diseases، جلد ۱۷، شماره ۲، صفحات ۱۰۵-۱۱۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of liver enzymes changes and association with outcome in hospitalized COVID-19 patients in Jordan |
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| چکیده انگلیسی مقاله |
Background: Abnormal liver enzymes have been reported in COVID-19 patients with severe presentation. However, limited studies exist in our region regarding the impact of COVID-19 on the liver’s function, thus, we aimed to investigate liver enzymes changes and association with prognosis and outcome in hospitalized COVID-19 patients in Jordan. Methods: This retrospective cohort’s study included 359 COVID-19 positive patients who were admitted to Ministry of Health hospitals all around Jordan during the period of the second pandemic wave of COVID-19 in Jordan. Data such as liver enzymes, patients demographics and outcomes were collected and statistically analysed. Results: Approximately 39.55% of patients had elevated liver enzymes, and 5.85% were elevated more than twice the upper limit of normal. Among these patients, 40.8% had both AST and ALT elevation, 52.1% had AST elevation alone, and 7.0% had ALT elevation alone. Factors associated with worse prognosis and outcome were older age, males and comorbid autoimmune conditions. The peak and at-discharge values of AST and ALT showed significant differences. Conclusion: Liver enzyme abnormality is common among COVID-19 patients with AST being the most common abnormality. AST and ALT elevation can be associated with longer hospital stay, older age and males. |
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| کلیدواژه‌های انگلیسی مقاله |
hepatitis, liver injury, viral infection |
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| نویسندگان مقاله |
| Tarek Mazzawi
Faculty of Medicine, Al-Blaqa Applied University, Slat, Jordan
| Hadeel Alshahwan
Faculty of Medicine, Al-Blaqa Applied University, Slat, Jordan
| Ban Aladamat
Faculty of Medicine, Al-Blaqa Applied University, Slat, Jordan
| Sara Al.Nsour
Faculty of Medicine, Al-Blaqa Applied University, Slat, Jordan
| Leen Asfour
Faculty of Medicine, Al-Blaqa Applied University, Slat, Jordan
| Dana Abu Hanak
Faculty of Medicine, Al-Blaqa Applied University, Slat, Jordan
| Seema Al-Shehab
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| نشانی اینترنتی |
http://mejdd.org/index.php/mejdd/article/view/3096 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.15171/middle east j di.v17i2.3096 |
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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