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Journal of Dentistry, Shiraz University of Medical Sciences، جلد ۱۵، شماره ۳، صفحات ۹۱-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی A Clinical, Histopathological and Immunohistochemical Approach to the Bewildering Diagnosis of Keratoacanthoma
چکیده انگلیسی مقاله Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically. This article aims to illustrate and explicate some of these complicated issues by presenting two cases of KA and a relevant review of literature. It also targets the clinical, histopathologic, and immuno-histochemical features of these two cases. Both presented lesions of this study had appeared on the vermilion border of the lower lip and no vascular or perineural invasion was observed. The results of the immuno-histochemical survey, particularly in staining with marker CD30, confirmed the differential diagnosis of keratoacanthoma from keratoacanthoma-like pseudocarcinomatous proliferations which was consequent to the CD30 + lymphoid infiltration. Histopathological and immunohistochemical investigation is necessary to disprove the invasive biologic behavior of keratoacanthoma and also to refute all conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia. Key Words: Immunohistochemistry; Keratoacanthoma; KA; CD30
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله معصومه زرگران | massoumeh zargaran
dental research center and dept. of oral and maxillofacial pathology, school of dentistry, hamadan university of medical sciences, hamadan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

فهیمه بقایی | fahimeh baghaei
dept. of oral and maxillofacial pathology, school of dentistry, hamadan university of medical sciences, hamadan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

نشانی اینترنتی http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/738
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/331/article-331-351300.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Literature Review
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