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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۲، صفحات ۱۶۰-۱۶۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Inhibitory effects of different fractions of Nepeta satureioides on melanin synthesis through reducing oxidative stress
چکیده انگلیسی مقاله Nepeta satureioides Boiss. has been used in traditional medicine of eastern countries and is famous for its medicinal properties. The aim of this study was to evaluate the effect of methanol (MeOH), n -hexane and dichloromethane (CH 2 Cl 2 ) fractions of the extract on melanin synthesis and oxidative stress in B16F10 melanoma cell line. The B16F10 cell line viability after treatment with increasing concentrations of different fractions of the plant (5-60 µg/mL) was measured using MTT assay. The inhibitory effect on synthesis of melanin, mushroom tyrosinase activity, cellular tyrosinase and oxidative stress were determined by the colorimetric and fluorometric methods. The data showed that at concentrations below 60 µg/mL, fractions did not show significant toxicity on melanoma cells. The amount of melanin synthesis by MeOH and CH 2 Cl 2 fractions and mushroom tyrosinase activity by the MeOH fraction declined in B16F10 cells. In addition to the capacity of MeOH, n- hexane and CH 2 Cl 2 fractions in decreasing the amount of reactive oxygen species (ROS) in melanoma cells, all fractions revealed remarkable antioxidant activity. The melanogenesis inhibitory and antioxidant effects of N. satureioides on B16F10 cells may suggest this plant as a new pharmaceutical agent in reducing skin pigment and skin aging in cosmetic industry.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله سید احمد امامی | seyed ahmad emami
1department of pharmacognosy, school of pharmacy, mashhad university of medical sciences, mashhad, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

رضوان یزدیان رباطی | rezvan yazdian robati
2department of pharmaceutical biotechnology, school of pharmacy, mashhad university of medical sciences, mashhad, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد صادقی | mohammad sadeghi
1department of pharmacognosy, school of pharmacy, mashhad university of medical sciences, mashhad, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

جواد بهارآرا | javad baharara
3department of animal biology, faculty of biological sciences, kharazmi university, tehran, i.r. iran.


الهه امینی | elaheh amini
4research center for applied biology, mashhad branch, islamic azad university, mashhad, i.r. iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

فرزانه سالک | farzaneh salek
5department of biology, faculty of sciences, mashhad branch, islamic azad university, mashhad, i.r. iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

زهرا طیرانی نجاران | zahra tayarani najaran
6department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1756
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-350606.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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