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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۲، صفحات ۱۲۸-۱۳۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Preparation and in vitro-in vivo evaluation of acyclovir floating tablets
چکیده انگلیسی مقاله In the current study, floating dosage form containing acyclovir was developed to increase its oral bioavailability. Effervescent floating tablets containing 200 mg acyclovir were prepared by direct compression method with three different rate controlling polymers including Hydroxypropyl methylcellulose K4M, Carbapol 934, and Polyvinylpyrrolidone. Optimized formulation showed good floating properties and in vitro drug release characteristics with mean dissolution time and dissolution efficacy of about 4.76 h and 54.33%, respectively. X-ray radiography exhibited that the tablet would reside in the stomach for about 5 ± 0.7 h. After oral administration of floating tablet containing 200 mg acyclovir, the C max , T max , and AUC 0–∞ of optimized gastroretentive formulation were found to be 551 ± 141 ng/mL, 2.75 ± 0.25 h and 3761 ± 909.6 ng/mL/h, respectively.
کلیدواژه‌های انگلیسی مقاله Acyclovir,Floating tablet,HPLC,X-ray radiography
نویسندگان مقاله رحیم بحری نجفی | rahim bahri najafi
1department of pharmaceutics and novel drug delivery systems research center, school of pharmacy and pharmaceutical science, isfahan university of medical science, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

ابوالفضل مصطفوی | abolfazl mostafavi
1department of pharmaceutics and novel drug delivery systems research center, school of pharmacy and pharmaceutical science, isfahan university of medical science, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

ناصر توکلی | naser tavakoli
1department of pharmaceutics and novel drug delivery systems research center, school of pharmacy and pharmaceutical science, isfahan university of medical science, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

سمیه تیموری | somayeh taymouri
1department of pharmaceutics and novel drug delivery systems research center, school of pharmacy and pharmaceutical science, isfahan university of medical science, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

محمد مهدی شهرکی | mohammad mehdi shahraki
2department of pharmaceutics, school of pharmacy and pharmaceutical science, isfahan university of medical science, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1752
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-350602.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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