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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۲، صفحات ۱۱۹-۱۲۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effect of epicatechin on oxidative stress and mitochondrial damage induced by homocycteine using isolated rat hippocampus mitochondria
چکیده انگلیسی مقاله Oxidative stress and mitochondrial dysfunction are the main suggested mechanisms for neurodegenerative diseases. In this study, we have evaluated the effects of epicatechin (EC) on mitochondrial damage induced by homocycteine (Hcy) using isolated rat hippocampus mitochondria in vivo . EC (50 mg/kg) was gavaged daily for a period of 10 days, starting 5 days prior to Hcy (0.5 μmol/μL) intra hippocampus injection in rats. Mitochondria were isolated from brain by different centrifuge techniques. Mitochondrial function was assayed by MTT test. Also, mitochondrial swelling and oxidative stress markers, such as reactive oxygen species (ROS), lipid peroxidation and glutathione (GSH), were assayed. Hcy induced mitochondrial dysfunction and swelling. Increase in ROS formation, lipid peroxidation, and decreased GSH were observed after Hcy treatment in isolated brain mitochondria. Furthermore, oral administration of EC significantly decreased the lipid peroxidation and ROS levels and also increased GSH levels. Also, EC treatment significantly improved mitochondrial function. As EC indicated protective effects against oxidative stress and mitochondrial damage induced by Hcy, it is suggested for further trials for prevention or treatments of neurodegenerative disorders such as Alzheimer disease.
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نویسندگان مقاله فاطمه شکی | fatemeh shaki
1department of toxicology and pharmacology and pharmaceutical sciences research center, faculty of pharmacy, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

یعقوب شایسته | yaghoub shayeste
1department of toxicology and pharmacology and pharmaceutical sciences research center, faculty of pharmacy, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

محمدکرمی | mohammad karami
1department of toxicology and pharmacology and pharmaceutical sciences research center, faculty of pharmacy, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

اسماعیل اکبری | esmaeil akbari
2department of physiology and pharmacology, faculty of medicine, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

مهدی رضایی | mahdi rezaei
1department of toxicology and pharmacology and pharmaceutical sciences research center, faculty of pharmacy, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

رامین عطایی | ramin ataee
1department of toxicology and pharmacology and pharmaceutical sciences research center, faculty of pharmacy, mazandaran university of medical sciences, sari, i.r. iran. 3thalassemia research center, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1758
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-350601.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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