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Iranian Journal of Parasitology، جلد ۱۲، شماره ۱، صفحات ۲۹-۳۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Genotyping, Drug Susceptibility and Prevalence Survey of Trichomonas vaginalis among Women Attending Gynecology Clinics in Hamadan, Western Iran, in 2014-2015 |
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| چکیده انگلیسی مقاله |
Background: In spite of sufficient knowledge about phenotypic variation of Trichomonas vaginalis , its genetic characteristics are poorly understood. We carried out a molecular epidemiology study in which in vitro metronidazole susceptibility of T. vaginalis isolates was considered. Methods : This study was conducted on 862 women admitted to Gynecology Clinics in Hamadan, west of Iran, during 2014-2015. After recording the socio-demographic and clinical characteristics of participants, vaginal swab samples were taken and subjected to microscopic examination, culture, in vitro sensitivity testing and PCR-restriction fragment length polymorphism (RFLP) analysis. Results: T. vaginalis was detected in 1.9% (16/862) of the samples using two parasitological methods. The all T. vaginalis isolates that subjected to drug susceptibility analysis were sensitive to metronidazole with MICs ranged from 0.4 to 12.8 µg/ml. T. vaginalis genotyping by using actin gene and PCR-RFLP analysis identified three actin type; A (9, 56%), I (6, 38%) and E (1, 6%). No significant correlation was observed between actin genotypes and their clinical manifestation ( P >0.05). Conclusion: The prevalence of T. vaginalis infection is not noticeable in the region and the most of isolates are hypersensitive to metronidazole. Further studies are needed to clarify the efficiency of the actin gene, as a reliable genetic marker, for molecular epidemiology of trichomoniasis. |
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| کلیدواژه‌های انگلیسی مقاله |
Genotype,Parasite,Prevalence,Trichomonas vaginalis,Iran |
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| نویسندگان مقاله |
محمد متینی | mohammad matini
dept. of medical parasitology and mycology, school of medicine, hamadan university of medical sciences, hamadan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
حسین رضایی | hossein rezaei
dept. of medical parasitology and mycology, school of medicine, hamadan university of medical sciences, hamadan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
محمد فلاح | mohammad fallah
dept. of medical parasitology and mycology, school of medicine, hamadan university of medical sciences, hamadan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
امیر حسین مقصود | amir hossein maghsood
dept. of medical parasitology and mycology, school of medicine, hamadan university of medical sciences, hamadan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
مسعود سعیدی جم | massoud saidijam
dept. of molecular medicine and genetics, school of medicine, hamadan university of medical sciences, hamadan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
طیبه شمسی احسان | tayebeh shamsi ehsan
dept. of medical parasitology and mycology, school of medicine, hamadan university of medical sciences, hamadan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://ijpa.tums.ac.ir/index.php/ijpa/article/view/1514 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/69/article-69-349945.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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