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Iranian Journal of Psychiatry، جلد ۱۲، شماره ۱، صفحات ۸-۱۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Environmental Enrichment Prevents Methamphetamine-Induced Spatial Memory Deficits and Obsessive-Compulsive Behavior in Rats |
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| چکیده انگلیسی مقاله |
Objective: This study was designed to examine the effect of environmental enrichment during methamphetamine (METH) dependency and withdrawal on methamphetamine-induced spatial learning and memory deficits and obsessive-compulsive behavior. Method: Adult male Wistar rats (200 ± 10 g) chronically received bi-daily doses of METH (2 mg/kg, sc, with 12 hours intervals) for 14 days. Rats reared in standard (SE) or enriched environment (EE) during the development of dependence on METH and withdrawal. Then, they were tested for spatial learning and memory (the water maze), and obsessive-compulsive behavior as grooming behavior in METH-withdrawn rats. Results: The results revealed that the Sal/EE and METH/EE rats reared in EE spent more time in the target zone on the water maze and displayed significantly increased proximity to the platform compared to their control groups. METH withdrawn rats reared in EE displayed less grooming behavior than METH/SE group. Conclusion : Our findings revealed EE ameliorates METH-induced spatial memory deficits and obsessive-compulsive behavior in rats. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
سمیرا حاج حیدری | samira hajheidari
faculty of psychology and educational sciences, university of semnan, semnan, iran.
سازمان اصلی تایید شده: دانشگاه سمنان (Semnan university)
حسین میلادی گرجی | hossein miladi gorji
2. laboratory of animal addiction models, research center and department of physiology, school of medicine, semnan university of medical sciences, semnan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)
ایمان الله بیگدلی | imanollah bigdeli
faculty of educational sciences and psychology, ferdowsi university of mashhad, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)
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| نشانی اینترنتی |
http://ijps.tums.ac.ir/index.php/ijps/article/view/696 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/64/article-64-349914.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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