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Nanomedicine Journal، جلد ۱۲، شماره ۲، صفحات ۲۳۸-۲۵۱
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عنوان انگلیسی Selenium nanoparticles loaded nanofibers ameliorate cardiac function after acute myocardial infarction in rat MI model
چکیده انگلیسی مقاله Objective(s): Acute myocardial infarction causes the heart to lose its proper function due to contractile dysfunction within the damaged ischemic cardiac tissue. Different studies have presented various cardiac patches based on different biomaterials to support the infarcted myocardium to recover cardiac function. Materials and Methods: In this study, we developed a nanofiber cardiac patch with antioxidant and antibacterial properties. Polycaprolactone (PCL) nanofibers were enriched with chitosan-coated selenium nanoparticles (Cs-SeNPs) using an electrospinning technique. Results: The PCL/Cs-SeNPs nanofibers, with an average diameter of 648.36±259.19 nm, displayed antioxidant properties in the DPPH assay. Additionally, viable cell count assessment demonstrated the antibacterial effects of PCL/Cs-SeNPs nanofibers against Staphylococcus aureus and Escherichia coli bacteria. MTT assay results revealed improved proliferation for the PCL/Cs-SeNPs nanofibers compared to the PCL nanofibers scaffold, with no significant cell toxicity. The SEM imaging and DAPI/Phalloidin staining supported the improved cell adhesion with well-expanded cytoskeleton of 3T3 cells on PCL/Cs-SeNPs nanofibers. In the rat model of myocardial infarction, improved cardiac function and reduced post-surgical adhesion were observed 28 days after surgery. Conclusion: The results of this study suggest that the PCL/Cs-SeNPs nanofibers cardiac patch can be considered a potent supportive strategy for myocardial rehabilitation after myocardial infarction.
کلیدواژه‌های انگلیسی مقاله Chitosan, Myocardial infarction, Nanofibers, Polycaprolactone, Selenium nanoparticles 
نویسندگان مقاله | Safieh Boroumand
Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran|Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Parisa Ahmadi
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Faraz Sigaroodi
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mohammad Mahdi Khani
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Fatemeh Ghanbari
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Shahram Rabbani
Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Hossein Ahmadi Tafti
Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Asieh Heirani-Tabasi
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Hossein Ghanbari
Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran|Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://nmj.mums.ac.ir/article_25204.html
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