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Nanomedicine Journal، جلد ۱۲، شماره ۲، صفحات ۲۱۶-۲۲۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Conductive composite nanoscaffold of polyurethane/rGO as skin regeneration agent animal model
چکیده انگلیسی مقاله Objective(s): Traditional wound dressings primarily promote passive wound healing and infrequently promote active wound healing by influencing skin cell. It is known that electrical stimulation (ES) can control the actions of skin cells. In the present study, the conductive electrospun PU/rGO was designed and fabricated and its qualities as skin wound dressings in animal models were examined. Materials and Methods: In this study, nanocomposite PU (polyurethane)/rGO (reduce graphene oxide) was synthesized using an electrospinning process, investigated via scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), water contact angle, degradation studies, electrochemical impedance spectroscopy (EIS), bactericidal efficacy, hemolysis and MTT assay.  Then, the scaffolds were grafted in full-thickness wounds of animal rats and evaluated by wound closure and histological.Results: The results showed that the PU/rGO scaffold exhibited antibacterial activity in comparison with PU scaffold and viability showed a notable improvement in cell promotion. In the histopathological analysis, improved dermis development and collagen deposition at the healed wound area of the PU/rGO scaffold with electrical stimulation in comparison to other groups were observed. Conclusion: A PU/rGO scaffold with electrical stimulation could be an appropriate option for skin tissue engineering and wound healing.
کلیدواژه‌های انگلیسی مقاله Composite, Electrical Stimulation, Scaffold, Tissue engineering, Wound healing 
نویسندگان مقاله | Niloufar MolayeeAsl
Student Research Committee, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran|Department of Medical Nanotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran


| Mahmood Araghi
Department of Pathology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran


| Sayed Habib Kazemi
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran


| seyed Hojat Hosseini
Department of Physiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran|Zanjan Metabolic Diseases Research Center, Health and Metabolic Diseases Research Institute, Zanjan University of Medical Sciences, Zanjan, Iran


| Samad Nadri
Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran|Zanjan Metabolic Diseases Research Center, Health and Metabolic Diseases Research Institute, Zanjan University of Medical Sciences, Zanjan, Iran|Department of Medical Nanotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
نشانی اینترنتی https://nmj.mums.ac.ir/article_25105.html
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