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Middle East Journal of Digestive Diseases، جلد ۱۰، شماره ۱، صفحات ۶۸-۷۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Bidirectional Association between Gastroesophageal Reflux Disease and Bipolar Disorder: A Systematic Review and Meta-analysis of Longitudinal Studies |
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| چکیده انگلیسی مقاله |
Background: Gastroesophageal reflux disease (GERD) and bipolar disorder impose substantial global burdens on individuals and healthcare systems. Previous studies suggest a bidirectional association between GERD and bipolar disorder. Methods: This study adhered to PRISMA Guidelines, including a comprehensive search of PubMed and Scopus for observational longitudinal studies. Quality (risk of bias) assessment employed the Newcastle-Ottawa Scale, and RevMan version 5.3 facilitated meta-analysis. Results: Five longitudinal studies (161,888 patients) revealed a significant bidirectional link between GERD and bipolar disorder. Patients with GERD had a 2.29-fold higher risk of bipolar disorder (OR=2.29 [1.64, 3.21]; P< 0.001), while individuals with bipolar disorder had a 2.80-fold higher risk of GERD (OR=2.80 [1.36, 5.76]; P=0.005). This study also identified independent risk factors, including sex, age under 60 years, and alcohol consumption disorders, influencing the occurrence of bipolar disorder in patients with GERD, as well as there is an influence of the number of psychoactive drugs in the occurrence of GERD in patients with bipolar disorder. Conclusion: These findings highlight a bidirectional relationship between GERD and bipolar disorder, emphasizing the necessity for integrated care models and personalized treatment plans. The results underscore the importance of considering both gastrointestinal and mental health aspects in managing these interconnected conditions. |
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| کلیدواژه‌های انگلیسی مقاله |
Bidirectional, Bipolar disorder, Comorbidity, Gastroesophageal reflux disease, Meta-analysis, Systematic review |
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| نویسندگان مقاله |
| Rahma Nurita
Ciremai Military Hospital, Cirebon, West Java, Indonesia
| Adit Faturohman
Faculty of Medicine, Universitas Hang Tuah, Surabaya, East Java, Indonesia
| Febrina Mustika Santoso
Faculty of Medicine, Universitas Diponegoro, Semarang, Central Java, Indonesia
| Bianca Magdalena
Department of Anatomy and Embryology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
| Muhana Fawwazy Ilyas
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| نشانی اینترنتی |
http://mejdd.org/index.php/mejdd/article/view/3049 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Systematic Review |
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