این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Materials Forming، جلد ۱۱، شماره ۳، صفحات ۵۰-۶۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Fabrication and Evaluation of Diopside/Gelatin Composite Scaffolds for Bone Tissue Engineering: A Comprehensive Study on Porosity, Bioactivity and Cell Interactions
چکیده انگلیسی مقاله This research investigates the development and characterization of a novel diopside/gelatin composite scaffold tailored to enhance bone tissue regeneration. The scaffold was fabricated using a space holder method followed by a gelatin coating technique. Energy-dispersive X-ray spectroscopy (EDS) analysis confirmed the successful application of the gelatin coating on the diopside scaffold. Scanning electron microscopy (SEM) revealed a highly porous, interconnected architecture, which provides an optimal environment for cell infiltration, vascularization, and nutrient diffusion, thereby promoting bone ingrowth. Mechanical testing demonstrated that the composite scaffolds exhibit sufficient compressive strength and stiffness to withstand physiological loads, supporting new bone tissue formation. Biological evaluation revealed excellent biocompatibility, with the scaffolds supporting robust cell attachment and proliferation. Furthermore, the observed elevation in alkaline phosphatase (ALP) activity, a critical marker of osteogenic differentiation, highlights the scaffolds' osteoconductive potential and their ability to facilitate bone formation. The synergistic combination of diopside, a bioactive ceramic renowned for its biocompatibility and osteoconductive properties, and gelatin, a natural biopolymer providing a cell-friendly environment and enhancing cell adhesion, has resulted in a promising composite scaffold significantly improved for bone tissue engineering. Notably, the application of a gelatin coating on the diopside scaffold significantly improved cell interaction and attachment, improving the overall bioactivity of the construct. These findings underscore the potential of the diopside/gelatin composite scaffold for bone regeneration applications. Nevertheless, further in vivo investigation and clinical studies are necessary to fully validate the scaffold's efficacy and elucidate its potential for clinical studies. 
کلیدواژه‌های انگلیسی مقاله Bone Scaffold,Tissue Engineering,Diopside Scaffold,Gelatin Coating
نویسندگان مقاله H. Ghomi |
Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran

A. Shams |
Department of Stem Cells and Regenerative Medicine, Institute for Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran

نشانی اینترنتی https://ijmf.shirazu.ac.ir/article_7867_2cb83e2c88d18e99b6e93ec7adf5c0e8.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات