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Basic and Clinical Neuroscience، جلد ۱۵، شماره ۶، صفحات ۰-۰
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effects of Synbiotic Supplementation on Cognition and Activities of Daily Living in Older People with Alzheimer Disease: A Randomized, Double-Blind Trial
چکیده انگلیسی مقاله
Background: Dementia is a progressive neurodegenerative disorder and a significant healthcare concern increasing worldwide. The modulation of the gut-brain axis by gut microbiota might have favorable effects on ameliorating cognitive decline. We aimed to investigate whether synbiotics administration could enhance cognition and function in older adults with non-severe Alzheimer disease (AD).
Methods: This study was designed as a randomized, placebo-controlled, double-blind clinical trial to test the effects of synbiotic supplementation for 90 days (between August 2019 and February 2021). A synbiotics formulation or placebo was randomly allocated to older outpatients with mild to moderate AD. The intervention group took two capsules daily containing a mixture of 7 bacterial strains as probiotics and a prebiotic for 12 weeks. Mini-mental state examination (MMSE) and Barthel index evaluated participants' cognition and functional status. Pre-intervention and post-intervention fasting blood samples were obtained to compare their serum albumin, fasting blood sugar (FBS), 25(OH) vitamin D, and lipid profile.
Results: A total of 60 patients with a mean age of 77 years were recruited. After 12 weeks of synbiotic supplementation, no significant improvement was detected in the MMSE score (P=0.53) and Barthel index (P=0.43). Furthermore, metabolic parameters including fasting blood sugar (P=0.92), triglyceride (P=0.48), total cholesterol (P=0.74), high-density lipoprotein (P=0.54), low-density lipoprotein (P=0.79), serum albumin (P=0.28) and 25(OH) vitamin D levels (P=0.67) were not different before and after synbiotic administration.
Conclusion: This study does not support the idea that short-term synbiotic supplementation could enhance cognitive and physical function in older patients with mild to moderate AD.
کلیدواژه‌های انگلیسی مقاله Synbiotics, Cognitive function, Activity of daily living, Elderly, Alzheimer disease ​​​​​​​
نویسندگان مقاله | Mahdieh Mehmandoust
Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Shima Raeesi
Department of Geriatric Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Rezvan Hashemi
Department of Geriatric Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Mohammad Bidkhori
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.


| Alireza Namazi Shabestari
Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Fatemeh Dashti
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.


| Farzaneh Asoudeh
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.


| Zahra Vahabi
Memory and Behavioral Neurology Division, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-4648-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Clinical Neuroscience
نوع مقاله منتشر شده Original
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