این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Kerman University of Medical Sciences، جلد ۳۱، شماره ۶، صفحات ۳۰۵-۳۱۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Concomitant L-carnitine supplementation and exercise training affects apoptosis in male rats
چکیده انگلیسی مقاله Background: Apoptosis is a defensive measure that removes dysfunctional cells. Exercise training has a broad spectrum of benefits that influence apoptosis and cell viability. L-carnitine (LCAR), a supplement nowadays, has shown beneficial effects against cell death. We investigated the simultaneous effect of exercise training (acute exercise [AE] and high-intensity interval training [HIIT]) and LCAR supplementation on the proteins involved in apoptosis. The animals were anesthetized twenty-four hours after the conclusion of the final training session.
Methods: Forty-eight male Wistar rats (210±10 g) were assigned to six groups (n=8) as follows: Control, LCAR (200 mg/kg/d LCAR, IP), AE, HIIT, LCAR+AE, and LCAR+HIIT. The animals were anesthetized and sacrificed twenty-four hours after the last training session; the rats’ blood sample was collected, and the serum was separated. The serum Bcl-2 levels, as an anti-apoptotic factor, and caspase-3 and BAX, as proapoptotic factors, were measured using specific ELISA kits.
Results: AE increased apoptosis, but HIIT’s effects were almost neutral. LCAR administration in groups that performed either AE or HIIT significantly attenuated apoptosis. However, in group 6 (LCAR+HIIT), the anti-apoptotic effects were noteworthy because LCAR+HIIT significantly increased Bcl-2 and reduced caspase-3 levels compared to the control group.
Conclusion: HIIT improved cell viability through increasing Bcl-2 levels, and LCAR strengthened HIIT’s anti-apoptotic properties. AE increased proapoptotic proteins, and LCAR modified the elevated proapoptotic markers in the AE group. Therefore, LCAR may be considered a promising supplement against exercise-mediated injury. This study can be extended to humans to evaluate the beneficial effects of LCAR+HIIT and LCAR+AE.
کلیدواژه‌های انگلیسی مقاله L-carnitine,Apoptosis,Bcl-2,Exercise
نویسندگان مقاله Beydolah Shahouzehi |
Student Research Committee, Kerman University of Medical Science, Kerman, Iran

Banafsheh Daneshmand |
Department of Physiology (Sport Science), Central Tehran Branch, Islamic Azad University, Tehran, Iran

Mahdieh Nazari-Robati |
Department of Clinical Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Soheil Aminizadeh |
Department of Physiology and Pharmacology, Afzalipour School of Medicine, and Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Yaser Masoumi-Ardakani |
Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

نشانی اینترنتی https://jkmu.kmu.ac.ir/article_92634_4318e9e692568f7396536669b1db31e0.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات