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Iranian Journal of Psychiatry، جلد ۲۰، شماره ۱، صفحات ۱-۹
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عنوان انگلیسی Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
چکیده انگلیسی مقاله Objective: Schizophrenia which is a chronic disabling burdensome psychotic disorder has been treated with different antipsychotic medications. Some studies have reported a possible correlation between deficiency in minerals, nutrients and vitamins — mainly group B vitamins — and the development of schizophrenia. In the present study, we aimed to examine the effect of the B vitamin group as an adjuvant treatment to antipsychotics in individuals with chronic schizophrenia. Method: In a randomized, double-blind clinical trial study, involving two groups of 25 patients with chronic schizophrenia, we compared the effects of a 12-week adjuvant treatment with a combination of B vitamins — B1 (15mg), B2 (15mg), B6 (10mg), B12 (10µg) and nicotinamide (50 mg) — with a placebo. The impact on negative, positive and cognitive symptoms of schizophrenia was assessed for both groups before the intervention (T0) and at 4, 8 and 12 weeks after the intervention (T1, T2, and T3, respectively). Results: Following the treatment, negative symptoms scores decreased in the treatment group at 12 weeks following the beginning of the treatment (F (4, 45) = 464.7, P < 0.0001). Although a trend toward improvement in positive symptoms and cognitive scores was seen, these changes were not significant. Conclusion: Our results suggest that selecting the group B vitamins as an adjuvant treatment to the antipsychotics may have beneficial effects on improving negative symptoms of patients with chronic schizophrenia.
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نویسندگان مقاله | Somayeh Agmashe
Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.


| Gita Sadighi
Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.


| Narges Radman
Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Robabeh Mazinani
Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
نشانی اینترنتی https://ijps.tums.ac.ir/index.php/ijps/article/view/3798
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