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Journal of Kerman University of Medical Sciences، جلد ۳۱، شماره ۵، صفحات ۲۳۸-۲۴۲
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عنوان انگلیسی The Effect of High-Intensity Interval Training in the Presence of L-Carnitine on the Expression of MCT1, PGC-1, and CS in the Liver of Male Wistar Rats
چکیده انگلیسی مقاله Background: T Liver oxidative metabolism disorder is dependent on several factors that lead to liver diseases like non-alcoholic fatty liver disease. Our hypothesis was that the combination of high-intensity interval training (HIIT) and L-carnitine affects the expression of citrate synthase (CS), PGC-1α, and monocarboxylate transporter 1 (MCT1) in the liver of male Wistar rats.
Methods: Thirty-two male Wistar rats were divided into four groups (n=8): control, L-carnitine (200 mg/kg/d, four weeks, IP), HIIT, and HIIT+L-carnitine (200 mg/kg/d, four weeks, IP). HIIT training was performed for four weeks (five days a week); then, the animals were anesthetized, and their liver tissues were extracted for real-time PCR to measure MCT1, PGC-1α, and CS. SPSS 22 software was used to analyze the data obtained in different groups, with P<0.05 considered statistically significant.
Results: MCT1 expression significantly increased in the HIIT and HIIT+L-carnitine groups compared to the control group (P<0.001). PGC- 1α expression significantly increased in the HIIT+L-carnitine group compared to the control and L-carnitine groups (P<0.001). Also, PGC- 1α expression significantly increased in the HIIT group compared to the control group (P<0.001). Furthermore, CS expression significantly increased in all groups compared to the control group (P<0.001).
Conclusion: HIIT exercise combined with L-carnitine supplementation increases the expression of MCT1, PGC-1α, and CS in the liver. Therefore, it seems that performing HIIT exercises and taking L-carnitine supplements can prevent the consequences of fat accumulation in the liver.
 
کلیدواژه‌های انگلیسی مقاله high-intensity interval training,MCT1,PGC-1α,CS gene
نویسندگان مقاله Mahdiyeh Haj Hosseini |
Department of Physical Education and Sport Science,National University of Skills(NS),Tehran, Iran

Beydolah Shahouzehi |
Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Najmeh Sadat Hosseini |
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

نشانی اینترنتی https://jkmu.kmu.ac.ir/article_92303_7e67e023db3a0e2365f7a13aac5412c3.pdf
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