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Iranian Journal of Otorhinolaryngology، جلد ۳۶، شماره ۶، صفحات ۶۳۹-۶۴۶
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عنوان انگلیسی Cell cannibalism in oral precancerous and cancerous lesions
چکیده انگلیسی مقاله Introduction:Cellular cannibalism is defined as a process of non-apoptotic cell death. This phenomenon has been indicated to be associated with aggressiveness, anaplasia, invasiveness, and metastatic potential of various malignancies. The Aim of this study is the evaluation of cell cannibalism in oral dysplastic lesions and oral cancer.Materials and Methods:A total of 31 cases of squamous cell carcinoma (SCC), 30 epithelial dysplasia, and 36 hyperkeratosis (HK) were enrolled in this Cross-sectional study. All hematoxylin and eosin tissue sections were examined in 10 high-power fields for tumor cell cannibalism. Data were analyzed using the Kruskal-Wallis and Fisher's exact test.Results:Cell cannibalism was found in all cases of SCC, 58.3% of dysplastic lesions, and 3.7% of HK cases. The mean number of cells with cannibalism was 19.48± 4.94 in SCC patients, 1.03± 1.25 in dysplastic lesions, and 0.03± 0.18in HK with a significant difference (P<0.001). High grades dysplastic and cancerous lesions exhibited more cannibalistic cells (P=0.01, P= 0.27, respectively).Conclusions:In addition to oral SCC, cell cannibalism was found in oral epithelial dysplasia; which was significantly more in SCC. This phenomenon was in association with grades of differentiation and might be considered a potential criterion for malignant transformation and high-grade lesions.
کلیدواژه‌های انگلیسی مقاله Cannibalism, Carcinoma, Squamous Cell, Cytophagocytosis, Mouth Neoplasms
نویسندگان مقاله | Zohreh Jaafari-Ashkavandi
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.


| Azadeh Andisheh Tadbir
Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.


| Asa Rahmatabadi
Department of Oral & Maxillofacial Pathology, School of Dentistry, Iran University of Medical Sciences, Tehran, Iran. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.


| Seyed Hossein Owji
Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical sciences, Shiraz, Iran.
نشانی اینترنتی https://ijorl.mums.ac.ir/article_25127.html
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