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Iranian Biomedical Journal، جلد ۲۵، شماره ۳، صفحات ۱۵۷-۱۶۸
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عنوان انگلیسی Interaction between LINC-ROR and Stemness State in Gastric Cancer Cells with Helicobacter pylori Infection
چکیده انگلیسی مقاله Background: Large intergenic non-coding RNA regulator of reprogramming (LINC-ROR), as a cancer-related Long non-coding RNA, has vital roles in stem cell survival, pluripotency, differentiation, and self-renewal in human embryonic stem cell. However, cancer-related molecular mech­anisms, its functional roles, and clinical value of LINC-ROR in gastric cancer (GC) remain unclear. In this study, we aimed to investigate probable interplay between LINC-ROR with SALL4 stemness regulator and their role with the development of the disease. Methods: The mRNA expression profile of LINC-ROR and SALL4 was assessed in tumoral and adjacent non-cancerous tissues of GC patients, using quantitative real-time PCR. Results: Significant LINC-ROR underexpression and SALL4 overexpression were observed in 55.81% and 75.58% (p < 0.0001) of samples, respectively. The expression of LINC-ROR and SALL4 were significantly correlated with each other (p = 0.044). There was an association between the underexpression of LINC-ROR and sex, stage of tumor progression, tumor type, and location of tumor (p < 0.05), and Helicobacter pylori infection with SALL4 expression (p = 0.036). There were also significant correlations between concomitant mRNA expression of SALL4 and LINC-ROR in tumors located at distal noncardiac, positive for H. pylori infection, tumors with invasion into the muscle layer of the stomach, and grade II tumor (p < 0.05). Conclusion: The clinical results of the SALL4-LINC-ROR association propose a probable functional interaction between these markers in tumor maintenance and aggressiveness. Our study can help to understand one of the mechanisms involved in the progression of gastric cancer through the function of these regulators.
کلیدواژه‌های انگلیسی مقاله LINC-ROR, SALL4, Non-coding RNA
نویسندگان مقاله | Reihaneh Alsadat Mahmoudian
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Maryam Lotfi Gharaie
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Roya Abbaszadegan
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Mahdi Forghanifard
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran


| Mohammad Reza Abbaszadegan
Medical Genetics Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1906-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cancer Biology
نوع مقاله منتشر شده مقاله کامل
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