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Iranian Biomedical Journal، جلد ۲۶، شماره ۴، صفحات ۳۰۱-۳۱۲
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عنوان انگلیسی A Signature of Three microRNAs Is a Potential Diagnostic Biomarker for Glioblastoma
چکیده انگلیسی مقاله Background: Glioblastoma is the most common primary malignant neoplasm of the central nervous system. Despite progress in diagnosis and treatment, glioblastoma still has a poor prognosis. This study aimed to examine whether a signature of three candidate miRNAs (i.e. hsa-let-7c-5p, hsa-miR-206-5p, and hsa-miR-1909-5p) can be used as a diagnostic biomarker for distinguishing glioblastoma from healthy brain tissues.
Methods: In this study, 50 formalin‐fixed paraffin‐embedded (FFPE) glioblastoma tissue samples and 50 healthy tissue samples adjacent to tumor were included. The expression of each candidate miRNA (i.e. hsa-let-7c-5p, hsa-miR-206-5p, and hsa-miR-1909-5p) was measured using quantitative reverse transcription PCR. To show the roles of each miRNA and their biological effects on glioblastoma development and clinicopathological characteristics, in silico tools were used. ROC curves were performed to assess the diagnostic accuracy of each miRNA.
Results: Based on the results, hsa-let-7c-5p and hsa-miR-206-5p were downregulated, while hsa-miR-1909-5p was upregulated in glioblastoma tumors compared to healthy samples. No association was detected between the expression of each candidate miRNA and sex. Except for hsa-let-7c-5p, other miRNAs did not correlate with age status. ROC curve analysis indicated that the signature of candidate miRNAs is a potential biomarker distinguishing between glioblastoma and healthy samples. Only hsa-miR-206-5p suggested the association with poor prognosis in glioblastoma patients.
Conclusion: Our findings revealed that the signature of three miRNAs is capable of distinguishing glioblastoma tumor and healthy tissues. These results are beneficial for the clinical management of glioblastoma patients.
کلیدواژه‌های انگلیسی مقاله Inflammation, Gastric cancer, Gene expression, Pattern recognition receptors, RNA-seq
نویسندگان مقاله | Ali Hosein Yazdi
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran


| Vajiheh Zarrinpour
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran


| Elham Moslemi
Cellular and Molecular Biology Department, Islamic Azad University, Tehran East Branch, Tehran, Iran


| Mohammad Mahdi Forghanifard
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4855-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cancer Biology
نوع مقاله منتشر شده مقاله کامل
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