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Iranian Biomedical Journal، جلد ۲۷، شماره ۴، صفحات ۲۱۴-۲۱۸
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Evaluation of mRNA Expression of CD244 and Its Adapter Molecules in CD8+ T Cells in Acute Leukemia
چکیده انگلیسی مقاله
Background: This study investigated the role of the immune-checkpoint receptor (ICR), CD244, and its adapter molecules, in CD8+ T cells in acute leukemia.
Methods: Blood samples were obtained from 21 acute lymphoblastic leukemia (ALL) and 6 acute myeloid leukemia (AML) patients and 20 control subjects. Relative gene expression of CD244, immune receptor tyrosine-based switch motif-associated protein (SA), EWS/FLI1-activated transcript 2 (EAT-2), and LncRNA-GSTT1-AS1 were evaluated using quantitative reverse transcription polymerase chain reaction.
Results: Expression of CD244, SAP, and EAT-2 were significantly lower in CD8+ T cells from ALL patients than those from control subjects. Interestingly, the expression of SAP was much lower than that of CD244, indicating a lower ratio of SAP to CD244. Also, SAP expression was significantly lower in AML patients compared to the control group. Expression of LncRNA-GSTT1-AS1 showed no significant difference in ALL and AML patients compared to control subjects.
Conclusion: The low SAP/CD244 expression ratio in CD8+ T cells in ALL suggests an inhibitory role for CD244 in ALL.
کلیدواژه‌های انگلیسی مقاله CD244 Expression in Acute Leukemia
نویسندگان مقاله | Maryam Mohammadi
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Hossein Asgarian-Omran
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Ahmad Najfi
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Reza Valadan
Molecular and Cell-Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran


| Hossein Karami
Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran Iran


| Mohammadd Naderisoraki
Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran Iran


| Ehsan Zaboli
Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran


| Mohammad Eslami
Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran


| Mohsen Tehrani
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5163-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cancer Biology
نوع مقاله منتشر شده مقاله کامل
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