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Iranian Biomedical Journal، جلد ۲۸، شماره ۲، صفحات ۷۱-۸۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Facile Green Synthesis of Iron Oxide Nanoparticles and Their Impact on Cytotoxicity, Antioxidative Properties and Bactericidal Activity
چکیده انگلیسی مقاله
Background: Bioreductive processes are quite potent, effective and affordable for the synthesis of green nanoparticles (NPs), as compared to the physical and chemical methods. The present study aimed to evaluate the bactericidal, antioxidative and anticancer activity of turmeric rhizome-iron oxide nanoparticles (FeONPs) derived from the turmeric rhizome (Curcuma amada) using ferric chloride as a precursor.
Methods: With focusing on the manufacture of FeONPs via  green approach, we characterized the NPs using FTIR, FT-Vis, DLS, and UV-Vis spectroscopy. The produced particles were tested for antibacterial, antioxidant, and anticancer properties. The synthesized NPs were also examined using the MDA-MB-231 human epithelial breast cancer cell line and NCI-60 cancer cell lines.
Results: The antioxidant activity of TR-FeONPs was concentration-dependent. The scavenging activity of TR-FeONPs was 76.09% at a concentration of 140 µg/ml. Using different concentrations of TR-FeONPs in the MTT assay against the MDA-MB-231 cell line indicated a reduction of less than 50% in cell viability at 125 µg/ml. Moreover, TR-FeONPs exhibited an effective bactericidal property. The gTR-FeONPs synthesized bioreductively were found to be effective in renal cancer, UO-31 cell line, with GI50 value of 66.64%.  
Conclusion: Our study showcases a sustainable method based on green chemistry principles to produce FeONPs utilizing turmeric rhizome. We anticipate that the FeONPs produced through this biosynthesis process could serve as a promising drug delivery system in cancer treatment
and as an effective antimicrobial agent against various diseases.
کلیدواژه‌های انگلیسی مقاله Antioxidants, Bactericidale activity, Green Synthesis, MDA-MB-231cells, Molecular docking
نویسندگان مقاله | Sejal S. Shah
Department of Bioinformatics, Faculty of Technology, Marwadi University, Rajkot, Gujarat, India


| Bhavika P. Turakhia
Department of Bioinformatics, Faculty of Technology, Marwadi University, Rajkot, Gujarat, India


| Nihar Purohit
Department of Life Sciences, Biotechnology Division, School of Science, GSFC University, Vadodara-391750, Gujarat, India


| Khushal M. Kapadiya
School of Science, Department of Chemistry, RK University, Rajkot, Gujarat, India


| Chita R. Sahoo
Central Research Laboratory, Institute of Medical Sciences & SUM Hospital, Siksha O Anusandhan Deemed to be University, Bhubaneswar 751003, Odisha, India


| Akhilesh Prajapati
Department of Life Sciences, Biotechnology Division, School of Science, GSFC University, Vadodara-391750, Gujarat, India
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5609-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cancer Biology
نوع مقاله منتشر شده مقاله کامل
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