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Medical Laboratory Journal، جلد ۱۰، شماره ۵، صفحات ۵۲-۵۷
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Age-Related Changes in Doxorubicin-Induced Oxidative Damage: Protective and Pretreatment Effects of Short-Term Aerobic Exercise |
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| چکیده انگلیسی مقاله |
ABSTRACT Background and Objective: Doxorubicin (DOX) is an effective anticancer drug. It has been shown that a short-term exercise performed prior to DOX-treatment has no effect on cardiotoxicity in young rats. In the present study, old and young rats were evaluated to determine the protective effects of pre-treatment with short-term exercise on DOX-induced oxidative damage in cardiac tissue. Methods: Forty-eight male Wistar rats were randomly divided into two groups of young and old, and later divided into three sub-groups of young+DOX, young+training+DOX, young+training+salin, old+DOX, old+training+DOX and old+training+salin. The training protocol included treadmill running for 25-39 min/day at 15-17 m/min, 5 days/week for three weeks. All treatments were carried out 24h after the last exercise bout. The rats were sacrificed 48h after DOX administration. Results: Although DOX injection significantly affected the cardiac tissue of old rats compared to young rats, pretreatment with endurance training in DOX-treated rats caused an increase in Heat shock protein (3.02% vs. 23.36) and superoxide dismutase (30.12% vs. 31.12), and a decrease in malondialdehyde (10.92% vs. 19.60) in both old and young rats. Conclusion: Although DOX-induced production of free radicals and cardiotoxicity in aged rats is more than that in young rats, the short-term aerobic exercise reduced the damaging effects of free radicals in the old rats more than in young ones. The concentration of antioxidant enzymes also increases with exercise in the old rats compared to young rats. Keywords: Cardiotoxicity, Doxorubicin, Oxidative Stress, Aerobic Exercise. |
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| نویسندگان مقاله |
سیده زلیخا هاشمی چاشمی | seyyede zolaikha hashemi chashmi
department of sport physiology, faculty of physical education and sport sciences, university of mazandaran, babolsar, iran
سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)
ولی اله دبیدی روشن | valiollah dabidi roshan
department of sport physiology, faculty of physical education and sport sciences, university of mazandaran, babolsar, iran
سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)
سهیل عزیزی | sohail azizi
department of laboratory medicine, faculty of allied medical sciences, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
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| نشانی اینترنتی |
http://goums.ac.ir/mljgoums/browse.php?a_code=A-10-1-426&slc_lang=en&sid=fa |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/168/article-168-326931.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
تحقیقی |
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