International Journal of Radiation Research، جلد ۱۵، شماره ۱، صفحات ۱۵-۲۳
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عنوان انگلیسی Genotype-phenotype association of TGF-β1 and GST with chemo-radiotherapy induced toxicity
چکیده انگلیسی مقاله Background: Normal tissue toxicity continues to remain as a major challenge for radiation oncologists for delivering the total dose to the tumour cells in cancer patients. Cellular, molecular and plasma based early biomarkers to predict the overreactions and non-overreactions of normal tissue toxicity before the initiation of radiotherapy can be valuable for personalised treatment. The aim of the current study was to analyse the interrelationship between polymorphisms in Glutathione S- Transferases (GSTs) and Transforming Growth Factor-β1 (TGF-ß1), the plasma level/activity of these proteins with the development of chemo-radiotherapy induced oral mucositis and skin reaction in head and neck cancer (HNC) patients. Materials and Methods: We analysed polymorphisms in TGF-β1 and GST by restriction digestion of the PCR amplified products and we also assessed circulating TGF-β1 levels and GST activity by Enzyme Linked Immunosorbent Assay (ELISA). Results: The results indicate that pre-radiotherapy plasma TGF-β1 levels and total GST activity has no correlation with radiation induced normal tissue skin reaction and oral mucositis in HNC patients. Conclusion: The selected polymorphisms in TGF-β1 and GST had no influence on TGF-β1 levels and total GST activity. Plasma TGF-β1 and GST activity was not affected by the presence of selected polymorphisms and lacks significance in predicting skin reaction and oral mucositis prior to chemo-radiotherapy.
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نویسندگان مقاله h v goutham | h v goutham
department of radiation biology amp;amp; toxicology, school of life sciences, manipal university, manipal, karnataka, india


کسری mumbrekar | k d mumbrekar
department of radiation biology amp;amp; toxicology, school of life sciences, manipal university, manipal, karnataka, india


n hitendra | n. hitendra
department of biotechnology, school of life sciences, manipal university, manipal, karnataka india.


بایرام محمد vadhiraja | b m vadhiraja
department of radiation oncology, manipal hospital, bangalore, karnataka, india


d j manipal university | d j manipal university
department of radiotherapy amp;amp; oncology, shiridi saibaba cancer hospital and research centre, kasturba hospital, manipal, karnataka, india


بی بی صدیقه shiridi saibaba cancer بیمارستان طحانی مرکز centre | b s shiridi saibaba cancer hospital and research centre
department of radiation biology amp;amp; toxicology, school of life sciences, manipal university, manipal, karnataka, india
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-645&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/42/article-42-326530.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده مرور و بررسی کلی
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