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Research in Pharmaceutical Sciences، جلد ۱۹، شماره ۴، صفحات ۴۱۵-۴۲۴
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عنوان انگلیسی The mutual effect of progesterone and vitamin D in an animal model of peripheral nerve injury
چکیده انگلیسی مقاله Background and purpose: Experimental and clinical studies have shown the potential role of progesterone in relieving neural injury. In addition, emerging data on vitamin D, a steroid hormone, have shown its neuroprotective properties. This study was designed to evaluate the mutual effect of vitamin D and progesterone on neuropathic pain (NP) in male rats. Experimental approach: Chronic constriction injury (CCI) was induced by inserting four ligatures around the sciatic nerve. Hyperalgesia and allodynia (cold and mechanical) were considered positive behavioral scores of NP. After surgery, Sprague Dawley male rats (weighing 200-250 g) were assigned into 7 groups.                       Vitamin D (250 and 500 units/kg/day, i.p.) and progesterone (4 and 6 mg/kg/day, i.p.) were injected from the 1 st day after CCI which continued for 21 days. Moreover, one group received the co-administration of vitamin D (500 units/kg/day, i.p.) and progesterone (6 mg/kg/day, i.p.) from the 1 st day until the 21 st post-CCI day. Behavioral tests were performed on the 7 th , 14 th , and 21 st days. Findings/Results: Daily supplementation with vitamin D (250 and 500 units/kg) did not alter nociception. Progesterone (4 and 6 mg/kg/day) was ineffective on thermal hyperalgesia. In the allodynia test, progesterone significantly decreased pain-related behaviors. The co-administration of vitamin D (500 units/kg/day) with progesterone (6 mg/kg/day) significantly relieved thermal hyperalgesia. Finally, the combination significantly decreased cold and mechanical allodynia. Conclusion and implications : This study showed the mutual effect of progesterone and vitamin D on NP for the first time. Hyperalgesia and allodynia were significantly relieved following co-administration of vitamin D and progesterone.
کلیدواژه‌های انگلیسی مقاله Allodynia,Hyperalgesia,Neuropathic pain,Progesterone,Vitamin D.
نویسندگان مقاله | Sedighe Nasirzadeh
Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran.


| Gholam Ali Hamidi
Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran.


| Hamid Reza Banafshe
Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran.


| Monireh Naderi Tehrani
Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran.


| Mohammad Shabani
Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran.


| Alireza Abed


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2262
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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