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Journal of Dentistry, Shiraz University of Medical Sciences، جلد ۱۸، شماره ۱، صفحات ۳۷-۰
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of Beta-Blockers on Number of Osteoblasts and Osteoclasts in Alveolar Socket Following Tooth Extraction in Wistar Rats
چکیده انگلیسی مقاله Statement of the Problem: Various researchers have suggested the use of β2-adrenergic receptor antagonists in prevention or treatment of bone resorption. Purpose: This study aimed to evaluate the effect of β2-adrenergic receptor antagonists on number of osteoclasts and osteoblasts involved in the healing of extraction socket of maxillary first molar in rats. Materials and Method: Maxillary first molars of 40 rats were extracted and divided into two groups. The test group received 0.1 mg/kg propranolol intraperitoneally daily. The controls received normal saline. At days 7, 14, 21 and 28 post-extraction, 5 rats were euthanized from each group. Maxillary bone was resected and the mean number of osteoblasts and osteoclasts in tooth socket was measured. Results: After 1 week, the number of osteoclasts in the controls was significantly higher than the test group. A significant increase in the number of osteoclasts in both groups at week 1 was observed compared to the following weeks ( p < 0.05). The number of osteoblasts in the controls at second week reached its maximum rate but stayed constant in the 3 rd and 4 th weeks. Osteoblasts in the test group increased similar to the controls but reached its maximum at 3 rd week and showed a significant increase compared to the controls ( p < 0.05). Conclusion: β2 adrenergic receptor antagonists decrease the number of osteoclasts and increase the number of osteoblasts during extraction socket healing. Keywords ● Osteoclast ● Osteoblast ● Propranolol ● Alveolar bone ● Rat
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله کتایون صدر | katayoun sadr
dept. of prosthodontics, faculty of dentistry, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

امیراعلا آغبالی | amirala aghbali
dept. of oral and maxillofacial pathology, faculty of dentistry, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

ماکان صدر | makan sadr
md, phd of anatomy, tracheal diseases research center, national research institute of tuberculosis and lung disease, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

حامد عباچی زاده | hamed abachizadeh
dept. of prosthodontics, faculty of dentistry, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

مریم عزیزی | maryam azizi
phd student of anatomy, dept. of anatomy, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهران مسگری عباسی | mehran mesgari abbasi
doctor of veterinary medicine, drug applied research center, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/1337
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/331/article-331-323398.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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