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Iranian Journal of Microbiology، جلد ۱۶، شماره ۳، صفحات ۴۲۱-۴۲۷
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عنوان انگلیسی Type-specific human papillomavirus prevalence in women referred for colposcopy in Tehran
چکیده انگلیسی مقاله Background and Objectives: Although several studies have been achieved on the frequency of the HPV types among women with cervical cancer in Iran, HPV-positive samples were in some cases directed to specific-primer genotyping of HPV 16 and 18. Therefore, the other HPV types are underestimated. Several studies have also reported a greater prevalence of HPV 16 in cervical cancer in Iran than in the world. To clarify these subjects, the distribution of HPV types in women referred for colposcopy in Tehran was investigated. Materials and Methods: In this cross-sectional study, a total of 148 cervical samples from women with normal, atypical squamous cells of undetermined significance, cervical intraepithelial neoplasia I-III, and invasive cervical cancer histopathology were included. HPV was detected by PCR assay and all HPV-positive specimens were subjected to direct nucleotide sequencing. Results: Our results demonstrated that the total prevalence of HPV was 92.5%. The five most common HPV types were HPV 16 (49.3%), 18 (14.8%), 6 (7.4%), 31 (4.1%), and 11 (2.7%). About the histopathological stage, HPV 16 and 18 were dominant in all studied groups. In cervical cancer, HPV 16 and 18 were detected in 60% and 20% of cases, respectively. Conclusion: HPV 16 and 18 were the most common in cervical cancer in Iran.
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نویسندگان مقاله | Rahim Soleimani-Jelodar
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Arash Arashkia
Department of Virology, Pasteur Institute of Iran, Tehran, Iran


| Zabihollah Shoja
Department of Virology, Pasteur Institute of Iran, Tehran, Iran


| Kimia Sharifian
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Setareh Akhavan
Department of Gynecology Oncology, Imam Khomeini Hospital Complex, Valiasr Hospital Tehran, Iran


| Fariba Yarandi
Department of Obstetrics and Gynecology, Yas Hospital, Tehran, Iran


| Somayeh Jalilvand
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4569
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