این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Microbiology، جلد ۱۶، شماره ۳، صفحات ۳۷۶-۳۸۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of collagen hydrogel containing Lavandula officinalis essential oil nanoemulsion in wound healing of infectious burn
چکیده انگلیسی مقاله Background and Objectives: The main cause of mortality in burn patients is infection from burns. Drug-resistant bacteria are the main causes of wound infection, so alternative antibiotic therapies hold significant importance. The objective of this study was to examine the impact of a collagen hydrogel that contains a nanoemulsion of Lavandula essential oil on the healing process of infected burn wounds. Materials and Methods: In this experimental study, 20 rats were randomly divided after applying burns with a 10 mm diameter hot plate and infecting the wounds with multidrug-resistant Pseudomonas aeruginosa into four groups, including a positive control, a negative control, the first experiment (collagen hydrogel), and the second experiment (collagen hydrogel containing Lavandula essential oil nanoemulsion). On the 4th, 11th, and 18th days, tissue samples were taken for pathology studies. The important parameters in burn wound healing with hematoxylin and eosin and Masson's trichrome staining methods were investigated and scored according to Abramov’s method. Results: Based on the pathology findings, experimental groups 1 and 2 compared to the negative and positive control groups were effective in rat infection wound healing. The hydrogel scaffold in the experimental groups increased fibroblasts and angiogenesis compared to the control groups. Epithelization was noticed only in the hydrogel group containing nanoemulsion. Conclusion: The study findings suggest that the use of collagen hydrogel with Lavandula essential oil nanoemulsion has potential as a wound dressing. This is because it has the potential to effectively promote healing and act as an antibacterial agent to prevent infections.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Hossein Teymouri
Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran


| Mojgan Mohammadimehr
Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran; Department of Laboratory Sciences, Faculty of Para Medicine, Aja University of Medical Sciences, Tehran, Iran


| Mohammad Ahanjan
Department of Medical Bacteriology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Somayeh Sheidaei
Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Majid Saeedi
Department of Pharmaceutics, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran


| Amir Mellati
Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4579
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات