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Iranian Journal of Microbiology، جلد ۱۶، شماره ۳، صفحات ۳۱۴-۳۲۲
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عنوان انگلیسی Evaluation of antibiotic resistance changes in Acinetobacter baumannii in the era of COVID-19 in Northern Iran
چکیده انگلیسی مقاله Background and Objectives: During the coronavirus pandemic, the overuse of antibiotics to reduce coinfections and mortality may be contributing to the rise of antimicrobial resistance. In this study, we aim to investigate the antibiotic resistance changes of Acinetobacter baumannii post-COVID-19 pandemic in Northern Iran. Materials and Methods: The current study is a cross-sectional study. Between 2022 and 2023, 2190 clinical samples were collected from patients with healthcare-associated infections (HAIs) at four hospitals in Sari, which served as corona centers after the COVID-19 pandemic. Antimicrobial sensitivity was determined using standard broth macro-dilution, and resistance genes were detected using multiplex PCR. Results: Based on the results co-amoxiclav had a resistance rate of 100%, while piperacillin/tazobactam showed the least resistance rate of 29.82%. In terms of GM MIC values, colistin was the most potent against multi-drug resistant isolates. The frequency of blaOXA-51, ampC, aphA6, and blaNDM genes were 100%, 99.12%, 90.35%, and 69.30% respectively. Conclusion: Our study revealed high multi-drug resistance rates. Piperacillin/tazobactam recommended for treating multidrug resistant Acinetobacter baumannii infections in Northern Iran.
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نویسندگان مقاله | Golnar Rahimzadeh
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran


| Reza Valadan
Department of Immunology and Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Shaghayegh Rezai
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Khosravi
Students Research Committee, Mazandaran University of Medical Sciences, Sari, Iran


| Laleh Vahedi Larijani
Department of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Somayeh Sheidaei
Department of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Ebrahim Nemati Hevelaee
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran


| Faezeh Sadat Movahedi
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran


| Raha Rezai
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran


| Mohammad Sadegh Rezai
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4627
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