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Nanomedicine Journal، جلد ۱۱، شماره ۳، صفحات ۳۲۰-۳۳۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Niosomal tannic acid drug delivery system: An efficient strategy against vancomycin-intermediate Staphylococcus aureus (VISA) infections |
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| چکیده انگلیسی مقاله |
Objective(s): Our study aimed to formulate a niosomal system for enhancing tannic acid’s antibacterial and antibiofilm activities against vancomycin-intermediate staphylococcus aureus (VISA). Materials and Methods: Niosomal tannic acid was formulated by the thin-film hydration technique, which their physicochemical attributes, including drug loading, particle size, zeta potential, morphology, encapsulation efficiency (EE%), polydispersity index (PDI), release profile, were evaluated. To investigate the cell viability of the prepared niosomes, the cytotoxicity effect was analyzed against the human foreskin fibroblast (HFF) cell line. Finally, the antibacterial and anti-biofilm activities of niosomal formulation were examined against VISA strains and compared tothe free drug.Results: Scanning electron microscopy images showed that the niosomal formulation incorporated tannic acid was homogeneous, spherical, and identical in size (151.9 nm). EE% and surface charge of the synthesized niosomes were 68.90% and -60 mV, respectively. The tannic acid-encapsulated niosomes showed a significant antibacterial potential in comparison with the free drug. Furthermore, niosomal tannic acid reduced the biofilm formation ability in all VISA strains and efficiently eradicated the formed bacterial biofilms at the same concentrations of the free drug.Conclusion: Niosomes, as vesicular-based nanoparticles, are known to be potent drug delivery vehicles due to numerous features such as non-toxicity, small size, sustained-release profile, and protection from pharmaceutical degradation. Niosomes have a high capacity to deliver wide range of antimicrobial agents, including natural compounds, which could be presented as a novel approach against bacterial infections, particularly VISA strains.Objective(s): Our study aimed to formulate a niosomal system for enhancing tannic acid’s antibacterial and antibiofilm activities against vancomycin-intermediate staphylococcus aureus (VISA). Materials and Methods: Niosomal tannic acid was formulated by the thin-film hydration technique, which their physicochemical attributes, including drug loading, particle size, zeta potential, morphology, encapsulation efficiency (EE%), polydispersity index (PDI), release profile, were evaluated. To investigate the cell viability of the prepared niosomes, the cytotoxicity effect was analyzed against the human foreskin fibroblast (HFF) cell line. Finally, the antibacterial and anti-biofilm activities of niosomal formulation were examined against VISA strains and compared tothe free drug.Results: Scanning electron microscopy images showed that the niosomal formulation incorporated tannic acid was homogeneous, spherical, and identical in size (151.9 nm). EE% and surface charge of the synthesized niosomes were 68.90% and -60 mV, respectively. The tannic acid-encapsulated niosomes showed a significant antibacterial potential in comparison with the free drug. Furthermore, niosomal tannic acid reduced the biofilm formation ability in all VISA strains and efficiently eradicated the formed bacterial biofilms at the same concentrations of the free drug.Conclusion: Niosomes, as vesicular-based nanoparticles, are known to be potent drug delivery vehicles due to numerous features such as non-toxicity, small size, sustained-release profile, and protection from pharmaceutical degradation. Niosomes have a high capacity to deliver wide range of antimicrobial agents, including natural compounds, which could be presented as a novel approach against bacterial infections, particularly VISA strains. |
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| کلیدواژه‌های انگلیسی مقاله |
Biofilm, Drug Delivery, Niosome, tannic acid, Vancomycin-intermediate Staphylococcus aureus (VISA) |
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| نویسندگان مقاله |
| Jaber Hemmati
Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran|Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
| Mohsen Chiani
Department of NanoBiotechnology, Pasteur Institute of Iran, Tehran, Iran
| Babak Asghari
Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
| Ghodratollah Roshanaei
Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
| Sara Soleimani Asl
Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
| Morvarid Shafiei
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
| Mohammad Arabestani
Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran|Infectious Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
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| نشانی اینترنتی |
https://nmj.mums.ac.ir/article_24162.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
مقاله پژوهشی |
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