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Basic and Clinical Neuroscience، جلد ۱۵، شماره ۲، صفحات ۱۵۷-۱۶۴
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عنوان انگلیسی Effect of Deep Brain Stimulation on Parkinson Disease Dementia: A Systematic Review and Meta-analysis
چکیده انگلیسی مقاله Introduction: Patients in the early stages of Parkinson disease (PD) may have subtle cognitive deficits, while overt cognitive deficits are usually manifestations of late-stage PD. There is still a debate on the outcome of deep brain stimulation (DBS) on the cognitive function of PD patients. This study aimed to investigate the effect of subthalamic nucleus (STN)-DBS on the dementia of PD patients after surgery compared to medical therapy and other procedures. 
Methods: We searched PubMed, Scopus, Cochrane Library, and Web of Science database on October 2020, with keywords: “Deep brain stimulation,” “Parkinson disease,” “dementia,” and “memory.” Reviews, abstracts, case presentations, and letters were excluded. 
Results: In total, 491 studies were screened after removing the duplicates. The screening results yielded 81 articles to be screened for eligibility. Finally, 6 studies were included in this meta-analysis for synthesis. Overall, 800 patients were included in this meta-analysis, using the Mattis dementia rating scale (MDRS) and descriptive data from the articles extracted to assess global dementia.
Conclusion: Our results suggest that the STN-DBS group showed a larger cognitive decline than the patients receiving the best medical treatment (BMT). However, comparing STN-DBS with globus pallidus interna stimulation and pallidotomy could not demonstrate a significant statistical effect on the global dementia of patients. More long-term studies with larger sample sizes are needed to validate current findings. 
کلیدواژه‌های انگلیسی مقاله Subthalamic nucleus, Parkinson disease, Deep brain stimulation, Parkinson disease dementia
نویسندگان مقاله | Ali Razmkon
Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.


| Saeed Abdollahifard
Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.


| Hirad Rezaei
Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.


| Amir Reza Bahadori
Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.


| Parham Eskandarzadeh
Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.


| AmirAli Rastegar Kazerooni
Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-3420-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Clinical Neuroscience
نوع مقاله منتشر شده Review
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